Comparative Profiling of Four Lignans (Phyllanthin, Hypophyllanthin, Nirtetralin, and Niranthin) in Nine Phyllanthus Species from India Using a Validated Reversed Phase HPLC-PDA Detection Method.

Background: Phyllanthus species exhibit a wide range of in vitro and in vivo pharmacological activities; however, little is known about the compounds present in the extracts that are responsible for such actions.

Objective: Development and validation of a simple reversed phase HPLC-PDA method for profiling of phyllanthin, hypophyllanthin, nirtetralin, and niranthin in extracts of Phyllanthus species was carried out.

Methods: Separation was achieved using an XBridge column® (150 × 4.

Rupture of rudimentary uterine horn pregnancy at 37 weeks gestation with fetal survival.

Pregnancy in rudimentary uterine horn is rare and associated with maternal and fetal mortality and morbidity. This patient presented with unexplained abdominal pain antenataly. Laparotomy for suspected abruption at 37 weeks revealed ruptured rudimentary horn with placenta accreta.