Publications by authors named "Kalmath G"
Int J Biol Macromol
April 2020
Article Synopsis
- 6-Thioguanine encapsulated chitosan nanoparticles (6-TG-CNPs) were successfully created using an ionic-gelation method, resulting in spherical nanoparticles with a size around 261.63 nm and a notable entrapment efficiency of 44.27%.
- The release profile of these nanoparticles indicated a greater sustained drug release at a lower pH (4.8) compared to a neutral pH (7.4), with 91.40% release over 48 hours at pH 4.8.
- When tested on cancer cell lines (MCF-7 and PA-1), 6-TG-CNPs showed lower IC values (indicating higher potency) compared to
