Karyomapping: a single centre's experience from application of methodology to ongoing pregnancy and live-birth rates.

This study aimed to determine whether karyomapping can be applied to couples requiring preimplantation genetic diagnosis (PGD) for single gene disorder (SGD) and/or chromosomal rearrangement. 75/82 (91.5%) and 6/82 (7.

Does hyaluronan improve embryo implantation?

Purpose Of Review: Taking into consideration the increasing interest on hyaluronan and its biological as well as physiological properties, this review will focus on the role of this molecule in human embryo implantation.

Recent Findings: Several studies have been performed up to date in order to assess whether the addition of hyaluronan in the human embryo culture system can improve pregnancy and implantation rates, including one retrospective and six randomized controlled trials. On the one hand, four of those studies showed significant increase in clinical pregnancy and/or implantation rates after using embryo transfer medium containing high concentration of hyaluronan.

Cryopreservation of human embryos by vitrification or slow freezing: a systematic review and meta-analysis.

Objective: To examine the literature systematically in order to identify prospective comparative trials answering the following question: Is vitrification of human embryos associated with a higher postthawing survival rate as compared with slow freezing?

Design: Systematic review and meta-analysis.

Setting: University-based hospital.

Patient(s): Not applicable.

Evaluation of a transfer medium containing high concentration of hyaluronan in human in vitro fertilization.

Objective: To examine whether a high concentration of recombinant hyaluronan in the embryo transfer (ET) medium can influence pregnancy rates in humans.

Design: Retrospective, matched group study.

Setting: Private and university hospital in vitro fertilization (IVF) units.

The effects of sperm quality on embryo development after intracytoplasmic sperm injection.

Purpose: To explore the possible relationship between sperm quality and embryo development, pregnancy and implantation rates, in patients undergoing intracytoplasmic sperm injection (ICSI).

Methods: Fertilization and cleavage rates, quality of embryos, blastocyst development, pregnancy and implantation rates were analyzed in 1020 embryos from 219 couples undergoing first ICSI treatment cycle. The couples were allocated in five groups, according to semen parameters: Group 1: patients with normal semen parameters, Group 2: patients with mild oligo-astheno-teratozoospermia, Group 3: patients with severe oligo-astheno-teratozoospermia, Group 4: patients with obstructive azoospermia, Group 5: patients with non-obstructive azoospermia.