Iodide supplementation: 200 micrograms daily or 1,500 micrograms weekly?

25 euthyroid volunteers were divided into two groups. Each participant of group A received 200 micrograms iodine in the form of diiodotyrosine per day for a period of eight weeks, i.e.

Hyperthyroidism with or without pyramidal lobe Graves' disease or disseminated autonomously functioning thyroid tissue?

I-123 thyroid scintigrams performed in 349 patients were evaluated with a focus on specific thyroid gland vestiges, namely a pyramidal lobe or a thyroglossal duct. The detection of these vestiges in patients with hyperthyroidiam is indicative of autoimmune hyperthyroidism. In Graves' disease, stimulating thyrotropin (TSH) receptor antibodies cause a significantly more frequent appearance of vestiges of the thyroglossal tract.

Bennhold's analbuminemia: a follow-up study of the first two cases (1953-1992).

A pair of siblings with analbuminemia were followed for 38 years. The female patient received replacement therapy with human serum albumin. Extreme lipodystrophy developed in this patient by the fourth decade of life.

[Iodine content in diet and excretion of iodine in urine].

The standard food for our volunteers, prepared in the central kitchen of the University Hospital of Tubingen, consisted of breakfast, warm lunch and cold supper and contained, on average, approximately 230 micrograms of iodine/day. It is generally assumed that an equilibrium is established between iodine intake from food and urinary iodine excretion. Hence, the amount of iodine excreted with the urine within 24 h may reflect the daily ingestion of iodine.

Inhibitory and disruptive effects of some antirheumatics on antigen-antibody complexes.

Purified antibodies to human serum albumin or to human gamma-globulin were used to study the direct influence of some antirheumatic drugs on the formation and disruption of immunoprecipitates. 125I-labelled human serum albumin and 125I-labelled human IgG served as indicators. The effects of the following drugs were described: diclofenac, monophenylbutazone, diphenylbutazone, ibuprofen, and metamizol.

Oxalic acid in saliva, teeth and tooth tartar.

Oxalic acid was determined in human saliva, teeth, tartar, and in animal teeth. Saliva from dentally healthy male subjects contained 0.10 +/- 0.

Direct effect of protirelin (TRH) on PB[123I] in autonomous thyroid adenoma.

In a retrospective study of 27 cases of iodine deficiency and/or latent primary hypothyroidism and in 16 cases of thyroid adenoma with hyperthyreosis the routine radioiodine uptake test was combined with a protirelin (TRH) test. After TRH infusion, [PB*I] and TSH increased significantly in all of these 27 patients who served as controls for the hyperthyroid patients. At the same time, the conversion rate Q rose in 14 of the control patients, but it dropped in 13 cases, thus indicating a TSH-induced discharge from the thyroid of radioiodine containing substances that were not bound to serum proteins.

Oxalate in the human thyroid gland.

Ninety-seven fixed surgical thyroid specimens and 63 unfixed and 40 fixed thyroid specimens from autopsies were examined for their oxalate content. Proteases were used to process the tissue, and the oxalate was determined with an enzymatic assay. The fixed samples were grouped into seven diagnostic categories (diffuse colloid goitre; partially diffuse, partially nodular colloid goitre; nodular colloid goitre; goitre with multifocal functional autonomy; non-functioning adenoma; unifocal functional autonomy; Graves' disease).

Isoelectric focussing of human thyroxine binding globulin (thyropexin) and human prealbumin (transthyretin).

Two batches of the highly purified thyroid hormone-binding plasma proteins, human thyropexin and transthyretin, which were prepared in gram quantities for use in animal experiments, were subjected to analysis by isoelectric focussing. Under these conditions, it was observed that human transthyretin was composed of two components. This was presumably due to the use of 8 mol/l urea.

Direct effects of protirelin (TRH) on cultured porcine thyrocytes.

In several cases of thyroid adenoma in which no TSH was detectable in the serum, a paradoxical decrease of PB123I and its conversion rate Q (PB123I/serum total radioactivity) was observed after infusion of protirelin (TRH). The possibile direct effect of TRH on thyrocytes was therefore studied in vitro. Porcine thyroid cells were cultured in NCTC-135 medium supplemented with a serum substitute and insulin.

Effects of human thyroxine-binding globulin and prealbumin on the reverse flow of thyroid hormones from extravascular space into the bloodstream in rabbits.

A plasma fraction rich in thyroid hormone-binding globulin (hTBG, human thyropexin) was injected iv into rabbits in order to see whether thyroid hormone concentrations in plasma would increase by return of T3 and T4 from the extravascular space. For this purpose, both [125I]T3 and [131I]T4 were simultaneously injected. After 1 h, or after 16 h in another series of experiments, 50 mg hTBG were injected iv.

Mathematical modelling of intravascular thyroid hormone stimulation by carrier proteins.

A simple mathematical model for the thyroid hormone stimulation in plasma after intravenous administration of pharmacological doses of thyroid hormone binding carrier proteins is described. The model concept is based on the observation of the time course of both radioactive labelled and unlabelled thyroid hormones before and after protein loading in rabbits. All model parameters are derived from experimental measurements in order to guarantee the identifiability with physiological data.

[Familial coincidence of hypertrophic cardiomyopathies and thyroxine-binding globulin deficiency (athyropexinemia) (author's transl)].

A twenty-five year old man was found to have simultaneous total deficiency of thyroxine-binding globulin ("thyropexin") and hereditary hypertrophic obstructive cardiomyopathy (HOCM). The thyroxine-binding capacity (RT3U), thyroid hormone levels, PB127I, PB131I and TBG (RIA) in serum were very low and TBG cap was zero. Trapping of radioiodine in the thyroid was enhanced.

[Thromboplastin activity of extracts of human thyroid glands (author's transl)].

Aqueous extracts of thyroid glands were prepared from 25 surgical specimens of 19 patients. The average prothrombin time of sixteen 3:4 diluted extracts of thyroids from 13 euthyroid patients was 16.8 +/- 2.