Publications by Kalle A Alanen

Publications by authors named "Kalle A Alanen"

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High-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer.

Paula Vainio John-Patrick Mpindi Pekka Kohonen Vidal Fey Tuomas Mirtti Kalle A Alanen

PLoS One

January 2013

Article Synopsis

Prostate cancer presents various types of diseases, emphasizing the need for more effective and personalized treatment strategies.
Utilizing gene expression data and RNA interference techniques, researchers identified 295 promising drug targets through bioinformatic analysis of over 9,000 human tissue samples.
The study highlighted several key targets, particularly AIM1, ERGIC1, and TPX2, which showed high expression in prostate cancer tissues and potential for developing targeted therapies, especially for ERG oncogene positive patients.

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Arachidonic acid pathway members PLA2G7, HPGD, EPHX2, and CYP4F8 identified as putative novel therapeutic targets in prostate cancer.

Paula Vainio Santosh Gupta Kirsi Ketola Tuomas Mirtti John-Patrick Mpindi Kalle A Alanen

Am J Pathol

February 2011

The arachidonic acid and prostaglandin pathway has been implicated in prostate carcinogenesis, but comprehensive studies of the individual members in this key pathway are lacking. Here, we first conducted a systematic bioinformatic study of the expression of 36 arachidonic acid pathway genes across 9783 human tissue samples. The results showed that the PLA2G7, HPGD, EPHX2, and CYP4F8 genes are highly expressed in prostate cancer.

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