[Effect of atorvastatin on pro-inflammatory status (in vivo and in vitro) in patients with essential hypertension and metabolic syndrome].

Aim: To study effect of atorvastatin on spontaneous production of cytokines and reactive oxygen species by mononuclear leukocytes of blood of hypertensive patients with metabolic syndrome in vivo and in vitro.

Material And Methods: We conducted an 8-week open prospective study on 36 patients with essential stage II hypertension associated with metabolic syndrome. Along with examination made in specialized cardiological clinic we assessed spontaneous production of cytokines and reactive oxygen species by blood mononuclear leukocytes during therapy with atorvastatin (in vivo).

[Prothrombotic state in patients with metabolic syndrome: an association with inflammation].

Aim: To comprehensively study hemostasis pathology and its association with the laboratory markers and mediators of inflammation in patients with metabolic syndrome (MS).

Subjects And Methods: One hundred and eleven patients with type 2 diabetes mellitus, who were diagnosed as having MS, were examined. Vascular-platelet and secondary hemostases and anticoagulant and fibrinolytic systems were evaluated, by performing the complete clinical, laboratory, and instrumental study accepted in a specialized endocrinology clinic.

[Effect of eprosartan on the hemostatic system in patients with chronic kidney disease associated with hereditary thrombophilia].

Aim: To study the effect of eprosartan, an angiotensin II type 1 (AT1) receptor blocker, with sympatholytic activity on the hemostatic system in patients with chronic kidney disease (CKD) associated with hereditary thrombophilia.

Subjects And Methods: The 12-week open-label uncontrolled trial included 31 patients with Stages I-II CKD: 15 patients with chronic glomerulonephritis and 16 with diabetic nephropathy burdening types 1 and 2 diabetes mellitus (DM) in 10 and 6 cases, respectively. In all the patients, CKD was associated with one of the heterozygous forms of thrombophilia: the polymorphic methylenetetrahydrofolate reductase gene variant C677T was found in 18 patients; the polymorphic coagulation factor V gene variant G1691A was in 9; and the polymorphic coagulation factor II gene variant G20210A in 4.

[The influence of amlodipine on transcapillary metabolism of oxygen during coronary heart disease with insulin resistance].

This three-week open uncontrolled study included 34 men (mean age 53.14+-1.19 yr) with coronary heart disease (CHD) and insulin resistance (HOMA >2.

[Pleiotropic effects of atorvastatin and dynamics of quality of life characteristics in patients with hypertensive disease and metabolic syndrome].

Aim: To study pleiotropic effects of atorvastatin during 8-week therapy of metabolic syndrome and estimate their relationship with dynamics of quality of life characteristics (QLC).

Material And Methods: This 8-week study included 36 patients with stage II hypertensive disease associated with metabolic syndrome (MS). Comprehensive clinical, laboratory and instrumental examination was supplemented by QLC assessment using the MOS SF-36 questionnaire.

[The biochemical markers of endothelium dysfunction in patients with diabetic nephropathy].

The article deals with studying the degree of increase of the von Willebrand factor and the concentration of endothelin-1 in blood plasma in the subgroups of patients with diabetes mellitus formed depending on of type of disease and presence of phenotype with affection of kidneys. The sampling of 176 patients with diabetes mellitus (65 patients with diabetes mellitus type 1, 111 patients with diabetes mellitus type II) was examined. The control group consisted of 30 healthy persons.

[Quality of life in patients with coronary heart disease associated with metabolic syndrome: results of factor analysis].

Aim: To identify the factors most substantially influencing the quality of life (QL) in patients with coronary heart disease (CHD) associated with metabolic syndrome (MS), by using the principal component method.

Subjects And Methods: One hundred and two male patients (mean age 48.6 +/- 1.

[Thermoresistance in Saccharomyces cerevisiae yeasts].

Under natural conditions, yeast Saccharomyces cerevisiae reproduce, as a rule, on the surface of solid or liquid medium. Thus, life cycle of yeast populations is substantially influenced by diurnal changes in ambient temperature. The pattern in the response of unrestricted yeast S.

[Effect of lipid free radical oxidation on renal functional status in patients with alcohol withdrawal syndrome].

Aim: to study the activity of free radical processes in patients with alcoholism and renal lesion (A+RL) and the implication of depressed efficiency of the regulatory mechanisms limiting the accumulation of highly toxic products of lipid free radical oxidation (LFRO) in the development of secondary nephropathy.

Subjects And Methods: Fifty-seven patients (mean age 31 +/- 2.8 years) with a 5-10 history of alcoholism who had been admitted to hospital for uncomplicated alcohol withdrawal syndrome were examined.

[Diastolic dysfunction of left ventricle in psoriatic patients with concomitant opisthorchiasis before and after antihelminthic therapy].

The aim of the study was to evaluate left ventricular diastolic function in psoriatic patients with chronic opisthrochosis (CO) before and after antihelminthic therapy. It included 75 patients with psoriasis and CO, 50 with psoriasis alone, 50 with CO, and 20 healthy subjects. All patients underwent standard echocardiographic examination in the M-, B-, and Doppler mode.

[Study of the emotional-and-personality sphere in patients with psoriasis concurrent with chronic opisthorchiasis].

The study was undertaken to evaluate the emotional-and-personality sphere in patients with psoriasis concurrent with chronic opisthorchiasis (CO). A hundred and fifty patients with psoriasis concurrent with CO, 100 psoriatic patients without helminthiasis, 100 patients with CO, and 30 healthy individuals were examined. The SMOL test was used to evaluate the emotional-and-personality sphere.

[The effectiveness of eprosartan in patients with chronic glomerulonephritis].

The subjects of this 12-week open non-controlled study of the organoprotective efficiency of eprosartan were 15 patients with chronic glomerulonephritis. The results of the investigation demonstrated high organoprotective activity of eprosartan in a dose of 600 mg a day, which manifested by anti-proteinuric and anti-hematuric effects, as well as positive changes in the parameters of intragromerular filtration, reduction of left ventricular hypertrophy and rigidity, and normalization of the vascularmotor function of the brachial arterial endothelium. To a large extent, the organoprotective activity of eprosartan depends on the unique pharmacodynamic profile of this drug, which is able to decrease excessive functional activity of the sympathetico-adrenal system, which is reflected in the dynamics of the cardiac rhythm dispersion parameters.

[Estimation of the levels of reactive and personality anxiety in patients with psoriasis concurrent with chronic opisthorchiasis].

The purpose of the study was to evaluate reactive and personality anxiety in patients with psoriasis concurrent with chronic opisthorchiasis (CO). Seventy-five patients with psoroasis concurrent with CO, 70 psoriatic patients without helminthism, 70 patients with CO, and 30 healthy individuals were examined. The level of anxiety at the moment of the study and that of personality anxiety were determined by the procedure described by Ch.

[The condition of immune homeostasis in patients with chronic renal failure].

The condition of immune homeostasis was studied in 100 patients with chronic renal failure (CRF), including 70 patients on hemodialysis. The patients displayed disbalance in the immune homeostasis characterized by a decrease in the number of CD3+, CD4+, and CD72+ cells, and phagocytosis intensification. Priority Th1-cell response of the immune system tends to intensify during the pre-dialysis period of CRF and becomes the most prominent at the terminal stage.

[The contingency of the parameters of the human brain electroencephalograms and electromagnetic fields of the Schuman resonator based on monitoring studies].

The contingency of the variations in the amplitude frequency parameters of the main modes of extremely-low-frequency resonances ionosphere waveguide (Shuman resonances) and changes in the parameters of human electroencephalograms in the range of the frequency "window" (6-16 Hz) was studied. The results of studies in the regimes of synchronized monitoring suggest that the contingency of the parameters of electroencephalograms and extremely-low-frequency resonances, expressed in the parameters of the cross-correlation function, is statistically significant and varies from 0.12 to 0.

[Clinical analysis of autonomic nervous system disorders in patients with psoriasis concurrent with chronic opisthorchiasis].

The study was undertaken to detect the characteristics of autonomic nervous system disorders in patients with psoriasis concurrent with chronic opisthorchiasis and, on their basis, to develop therapeutic manipulations. Examinations were made in 150 patients with psoriasis concurrent with chronic opisthorchiasis, 100 psoriatic patients without helminthiasis, 100 patients with chronic opisthorchiasis, and 30 healthy individuals. The questionnaire method developed and recommended for use by the All-Union Center of Autonomic Nervous System Diseases was employed for the screening diagnosis of vegetative dystonia syndrome and for the estimation of its severity.

[Quality of life of patients with old myocardial infarction on prolonged therapy with atenolol].

The purpose of the study was to evaluate the influence of atenolol, a selective, beta1-adrenoblocker, on the quality of life (QL) of patients with old myocardial infarction (MI). The subjects of this 12-month open uncontrolled study were 40 male patients aged 29 to 59 years (mean age 46.8 +/- 1.

[Influence of long-term therapy with enalapril on late postinfarction remodeling and functional state of the left ventricle in patients with diastolic heart failure.].

Enalapril (average dose 7,0+/-0.8 mg) was given for 12 weeks to 15 patients with preserved left ventricular (LV) systolic function who had survived large focal myocardial infarction small i, Ukrainian6 months before that. The use of enalapril was associated with 49% lessening of severity of clinical signs of heart failure (p<0.

[Antihypertensive and antiischemic effectiveness and safety of the AT1-receptor blocker irbesartranin arterial hypertension in patients with prior myocardial infarction].

Thirty males with prior myocardial infarction concurrent with arterial hypertension (AH) were examined to study the antihypertensive and antiischemic effects of the AT1-receptor blocker irbesartran. Group 1 comprised 12 (40%) patients with mild AH; Group 2 included 18 (60%) with moderate AH. In Group 2, the standard therapy with irbesartan in a single dose of 150 mg in the morning was supplemented by the beta1-adrenoblocker atenolol in the average daily dose of 31.

[Effects of carvedilol, atenolol and their combination with fosinopril on cardiac rhythm variability, clinicofunctional status and quality of life in patients with postinfarction left ventricular dysfunction].

Aim: To study effects of carvedilol and atenolol and their combination with fosinopril on heart rhythm variability (HRV, clinicofunctional status and quality of life in postmyocardial infarction patients with moderate chronic cardiac failure (CCF).

Material And Methods: An 8-week randomized open study enrolled 50 male patients (mean age 55.7 +/- 1.

[Anti-ischemic effects of trimetazidine in patients with post-infarction heart failure].

The antiishemic efficiency of course monotherapy with trimethazidine and its impact on myocardial perfusion were studied in patients with postinfarct dysfunction of the left ventricle (LV), which was associated with moderate heart failure (HF). This prospective controlled clinical study included 47 patients who had experienced myocardial infarction. The patients had also angina pectoris on exertion and NYHA Functional Classes (FC) II-III HF.

[Mechanism of biotropic effects of regional electromagnetic fields in patients with left ventricular ischemic dysfunction].

Aim: To study the role of disturbed autonomic regulation of the cardiovascular system in formation of the phenomenon of geliogeomagnetic sensitivity of patients with left ventricular ischemic dysfunction.

Material And Methods: 24-h synchronous monitoring of ECG and electromagnetic situation was made in 11 patients (mean age 49.4 +/- 0.

[Role of left ventricular systolic and diastolic dysfunction in clinical manifestations of chronic heart failure in patients with prior myocardial infarction].

Aim: To study the impact of systolic and systolic dysfunction of the left ventricle (LV) on the clinical manifestations of chronic heart failure (HF) in patients with prior myocardial infarction (MI).

Materials And Methods: 102 patients (mean age 47.4 +/- 0.

[State of lipid peroxidation, blood antioxidant defense in patients with myocardial infarction aggravated by circulatory insufficiency].

Aim: To study free radical processes in patients with myocardial infarction (MI) aggravated by heart failure.

Material And Methods: Forty seven patients taken to the clinic within the first 5 hours of MI were examined. The patients were divided into 2 groups: 1) those with left ventricular failure-complicated IM (n = 25); 2) those with uncomplicated MI (n = 22).

[Effect of long-term myocardial unloading with beta1-adrenoblocker atenolol on the state of the left ventricle in patients with moderate ischemic dysfunction of the heart as shown by doppler echocardiography].

Effects of 12-month therapy with a beta1-adrenoblocker atenolol on the process of late postinfarction remodeling of the heart and parameters of intracardiac hemodynamics were assessed in an open noncomparative study on 55 survivors of macrofocal myocardial infarction. Therapy with atenolol was associated with: (1) reduction of myocardial hypertrophy in patients with increased left ventricular myocardial mass without effect on its volume, cavity geometry and global systolic function; (2) normalization of initially 'hypertrophic' type of transmitral blood flow. Affecting mainly the demand component of the myocardial oxygen supply/demand ratio atenolol promoted inclusion of hibernating cardiomyocytes into active contraction.