Methionine-Derived Fluorescent Probes Targeting Mitochondria: A Tool for Real-Time Oxidative Stress Monitoring in Live Cells.

Reactive oxygen species (ROS) play crucial roles in both cell signaling and defense mechanisms. Hypochlorous acid (HOCl), a strong oxidant, aids the immune response by damaging pathogens. In this study, we developed two pyridinium-based fluorophores PSSM and PSSE for selective hypochlorite detection.

Tuning of a Hydrogen-Bonded Organic Framework by Liquid-Assisted Mechanosynthesis between Trans-Aconitic Acid and Isonicotinamide.

Cocrystallization of trans-aconitic acid (TACA) and isonicotinamide (INA) using liquid assisted mechanochemical grinding results in a unique supramolecular hydrogen-bonded organic framework (HOF) system encapsulating various organic solvents (liquid guest) with the formation of channel inclusion compounds. Dimension and shape of the framework is dependent on the solvent used during liquid assisted grinding (LAG). Although crystal structure of the cocrystal (TACA) ⋅ (INA) ⋅ (HO)@(INA) has been determined by Single Crystal X-ray diffraction (SCXRD), crystal structures of 3 cocrystal HOFs were determined by microcrystal electron diffraction (MicroED) and synchrotron X-ray diffraction due to lack of suitable single crystal.

Indian Trial of Tranexamic acid in Spontaneous Intracerebral Hemorrhage study protocol.

Rationale: Early mortality in intracerebral hemorrhage (ICH) is due to hematoma volume (HV) expansion, and there are no effective treatments available other than reduction in blood pressure. Tranexamic acid (TXA) a hemostatic drug that is widely available and safe can be a cost-effective treatment for ICH, if proven efficacious.

Hypothesis: Administration of TXA in ICH patients when given within 4.

Cancer Care and Nutrition Counseling: The Role of the Oncologist in Patient Learning and Behavior Change.

Background: Cancer remains a leading chronic disease in the United States with a high burden of disease and challenging treatment protocol. Nutrition is critically linked to long-term health outcomes and recovery rates among cancer patients, but there remains a persistent gap in clinician training regarding functional nutrition. This study interviews patients to understand their experiences of nutrition support they received while in cancer treatment.

Development of hydrogels from cell wall of Aspergillus oryzae containing chitin-glucan and wet spinning to monofilaments.

Fungal mycelium is emerging as a source for sustainable bio-based materials. Fungal biomass of Aspergillus oryzae was prepared by cultivation on bread waste hydrolysate to valorize this abundant food waste. Chitin-glucan-rich alkali-insoluble material (AIM) was isolated from fungal biomass, formed into hydrogels, and wet spun into monofilaments.

Geometrically twisted intra-inter-molecular cooperative interactions for an enhanced photo-response in an ORMOSIL-based host-guest system.

encapsulation of the 2-(2'-hydroxylphenyl)benzothiazole (HBT) fluorophore into organically modified silica (ORMOSIL) is recognized as a potential approach to increase the photocurrent conversion efficiency. Encapsulation resulted in a twisted geometrical configuration of HBT with an efficient charge transfer and increased carrier density, resulting in a 246% photo-response enhancement.

Exploring the Te(II)/Te(IV) Redox Couple of a Tellurorosamine Chromophore: Photophysical, Photochemical, and Electrochemical Studies.

A tellurorosamine dye [] undergoes aerobic photooxidation. Although Te(IV) species have been used in a number of oxidations, key Te(IV)-oxo and Te(IV)-bis(hydroxy) intermediates are challenging to study. Under aerobic irradiation with visible light, (λ = 600 nm) transforms into a Te(IV) species (λ = 669 nm).

Biomedical applications of graphene-based nanomaterials: recent progress, challenges, and prospects in highly sensitive biosensors.

Graphene-based nanomaterials (graphene, graphene oxide, reduced graphene oxide, graphene quantum dots, graphene-based nanocomposites, etc.) are emerging as an extremely important class of nanomaterials primarily because of their unique and advantageous physical, chemical, biological, and optoelectronic aspects. These features have resulted in uses across diverse areas of scientific research.

Copper removal efficacy and stress tolerance potential of sp. GUEco1015.

Cyanobacteria, a group of microalgae are the potent organism having the ability to survive in the copper rich environment and recently gained too much attention for their profuse proliferation in such water bodies. Amongst the members of cyanobacteria, the current study was conducted on sp. GUEco1015, collected from hydrocarbon rich water bodies of Assam, India.

Unraveling Ferroptosis Mechanisms: Tracking Cellular Viscosity with Small Molecular Fluorescent Probes.

Ferroptosis is a recently identified form of regulated cell death characterized by iron accumulation and lipid peroxidation. Numerous functions for ferroptosis have been identified in physiological as well as pathological processes, most notably in the treatment of cancer. The intricate balance of redox homeostasis is profoundly altered during ferroptosis, leading to alteration in cellular microenvironment.

Revisiting Dimorphs of 4-n-octyloxybenzoic Acid: Contrasting Mechanical Property and Surface Wettability.

4-n-octyloxy benzoic acid is known to exhibit liquid crystalline properties, and under normal pressure and temperature conditions, it exists as at least two crystalline polymorphs. We revisited the system and discovered that single crystals of one of the polymorphs display plastic deformation, whereas the other is brittle. n-octyl chains are arranged in an end-to-end fashion, forming slip planes in the plastically deformable polymorph, whereas they are interdigitated in the crystal structure of the brittle polymorph.

Advances in Bioelectrode Design for Developing Electrochemical Biosensors.

The critical performance factors such as selectivity, sensitivity, operational and storage stability, and response time of electrochemical biosensors are governed mainly by the function of their key component, the bioelectrode. Suitable design and fabrication strategies of the bioelectrode interface are essential for realizing the requisite performance of the biosensors for their practical utility. A multifaceted attempt to achieve this goal is visible from the vast literature exploring effective strategies for preparing, immobilizing, and stabilizing biorecognition elements on the electrode surface and efficient transduction of biochemical signals into electrical ones (i.

Identifying facilitators and barriers to culturally responsive communication for racial, ethnic, sexual, and gender minoritized patients when screened for COVID-19 vaccinations: A scoping review protocol.

Introduction: Racial, ethnic, sexual, and gender minoritized groups are considered historically excluded groups and have been disproportionately affected by the coronavirus disease 2019 (COVID-19) pandemic. The influence of social determinants of health (SDOH), including access to screening and treatment, and other systemic and structural factors are largely responsible for these disparities. Primary care practitioner (PCP) competence in culturally responsive screening practices will be critical to reducing the impact of systemic and structural factors serving as barriers to screening and treatment.

Triggering Degradation of Cellulose Acetate by Embedded Enzymes: Accelerated Enzymatic Degradation and Biodegradation under Simulated Composting Conditions.

A green strategy that significantly accelerates the biodegradation rate of cellulose acetate (CA) by triggering deacetylation was demonstrated. Lipase isolated from was immobilized on CA particles (immobilized lipase (IL)) by a physical entrapment method and further incorporated in CA films. After 40 days of aging in contact with external enzymes (lipase and cellulase), the number-average molecular weight () of CA/IL 5% decreased by 88%, while the of CA only exhibited a 48% reduction.

Identifying the barriers and facilitators to culturally responsive HIV and PrEP screening for racial, ethnic, sexual, and gender minoritized patients: A scoping review protocol.

Introduction: While mainstream messaging about human immunodeficiency virus (HIV) disparities continues to highlight individual risk-taking behavior among historically marginalized groups, including racial, ethnic, sexual, and gender minoritized patients, the effect of structural factors and social determinants of health (SDOH) on morbidity and mortality remain underestimated. Systemic barriers, including a failure of adequate and acceptable screening, play a significant role in the disparate rates of disease. Primary care practitioner (PCP) competency in culturally responsive screening practices is key to reducing the impact of structural factors on HIV rates and outcomes.

Automated image analysis method to detect and quantify fat cell infiltration in hematoxylin and eosin stained human pancreas histology images.

Fatty infiltration in pancreas leading to steatosis is a major risk factor in pancreas transplantation. Hematoxylin and eosin (H and E) is one of the common histological staining techniques that provides information on the tissue cytoarchitecture. Adipose (fat) cells accumulation in pancreas has been shown to impact beta cell survival, its endocrine function and pancreatic steatosis and can cause non-alcoholic fatty pancreas disease (NAFPD).

Synchronized redox pairs in metal oxide/hydroxide chemical analogues for an efficient oxygen evolution reaction.

A two-step electrodeposition of CoMnO and its chemical analogue CoMn(OH) directly over Ni-foam yields an excellent water oxidation overpotential of 260 mA cm with a Tafel slope of 29 mV dec and a four-fold increase in turnover frequency. The enhanced efficacy of the composite catalyst is realized through synchronized redox pairs and superior carrier transport.

Crystalline titanium-dioxide nanofinish impregnated on electrospun stereocomplex poly (lactic acid) as non-woven nanotextile with superhydrophilic, anti-shrinkage, dark dyeing and waste dye removal ability for sustainable application.

An environmentally friendly non-woven nanotextile has been prepared using enantiomeric pairs of poly (lactic acid) PLA by electrospinning technique. Solution blending of synthesized high molecular weight (⁓10 Da) poly (L-lactic acid) PLLA and poly (D-lactic acid), PDLA for prolonged time stirring produce solely stereocrystallites (sc). The high crosslinking effect of sc-PLA has played an important role, with multifunctional behaviour on the addition of anatase-TiO (a-TiO) in three different ways (Case-I-III).

Functionalized poly(lactic acid) based nano-fabric for anti-viral applications.

This study endeavoured to explore and fabricate antiviral and antibacterial facemasks using zinc (oligo-lactate) (ZL), developed through a microwave synthesis technique. The prepared nano-fabric layer has excellent antiviral and antibacterial properties against Newcastle Disease Virus (NDV) and and , respectively. Thermogravimetric analysis (TGA) of ZL shows a two-step thermal degradation, which confirms the formation of low molecular weight end group lactyl units with zinc ions.

Eisenia fetida for vermiconversion of waste biomass of medicinal herbs: Status of nutrients and stability parameters.

Vermiconversion possibility of waste biomass of two medicinal herbs Zingiber officinale and Curcuma longa has been investigated. The Eisenia fetida, an epigeic earthworm was used in the vermicomposting process. The vermicomposting caused shifting in pH towards neutral range, reduction in electrical conductivity, total organic carbon, C/N and C/P ratios whereas1.

Evaluation of seed associated endophytic bacteria from tolerant chilli cv. Firingi Jolokia for their biocontrol potential against bacterial wilt disease.

In this study, the seed endosphere of a bacterial wilt tolerant chilli cv. Firingi Jolokia was explored in order to find effective agents for bacterial wilt disease biocontrol. A total of 32 endophytic bacteria were isolated from freshly collected seeds and six isolates were selected based on R.

Engaging adolescents in changing behaviour (EACH-B): a study protocol for a cluster randomised controlled trial to improve dietary quality and physical activity.

Background: Poor diet and lack of physical activity are strongly linked to non-communicable disease risk, but modifying them is challenging. There is increasing recognition that adolescence is an important time to intervene; habits formed during this period tend to last, and physical and psychological changes during adolescence make it an important time to help individuals form healthier habits. Improving adolescents' health behaviours is important not only for their own health now and in adulthood, but also for the health of any future children.