In Vivo Assessment of a Triple Periodic Minimal Surface Based Biomimmetic Gyroid as an Implant Material in a Rabbit Tibia Model.

Biomimetic approaches to implant construction are a rising frontier in implantology. Triple Periodic Minimal Surface (TPMS)-based additively manufactured gyroid structures offer a mean curvature of zero, rendering this structure an ideal porous architecture. Previous studies have demonstrated the ability of these structures to effectively mimic the mechanical cues required for optimal implant construction.

In vitro probing of oxidized inulin cross-linked collagen-ZrO hybrid scaffolds for tissue engineering applications.

Hybrid biomaterials incorporated with active ingredients and metal nanoparticles are gaining more interest owing to their increased wound healing capacity. Here, we report the preparation of hybrid collagen scaffolds stabilized with oxidized inulin and ZrO nanoparticles for biomedical applications. The functional group changes in the oxidized inulin were ascertained using FT-IR spectroscopy.

A Critical Review on Polymeric Biomaterials for Biomedical Applications.

Natural and synthetic polymers have been explored for many years in the field of tissue engineering and regeneration. Researchers have developed many new strategies to design successful advanced polymeric biomaterials. In this review, we summarized the recent notable advancements in the preparation of smart polymeric biomaterials with self-healing and shape memory properties.

Bioengineered Hybrid Collagen Scaffold Tethered with Silver-Catechin Nanocomposite Modulates Angiogenesis and TGF-β Toward Scarless Healing in Chronic Deep Second Degree Infected Burns.

Management of burn wounds with diabetes and microbial infection is challenging in tissue engineering. The delayed wound healing further leads to scar formation in severe burn injury. Herein, a silver-catechin nanocomposite tethered collagen scaffold with angiogenic and antibacterial properties is developed to enable scarless healing in chronic wounds infected with Pseudomonas aeruginosa under diabetic conditions.

Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.

The existence of diabetes and microbial infection in burn wounds makes the healing process more complex. Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection. The spectroscopic analyses of the hybrid scaffolds reveal the chemical and structural integrity of collagen.

A ZnO-curcumin nanocomposite embedded hybrid collagen scaffold for effective scarless skin regeneration in acute burn injury.

Scar formation in severe burn injury is a major health concern. Herein, we developed a hybrid collagen scaffold with an incorporated ZnO-curcumin nanocomposite, which facilitates scarless wound healing. Biocompatibility and hemocompatibility studies unveiled that the hybrid scaffold is apt for in vivo wound healing studies.

A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation.

Creating hybrid materials with multifunctionality and robust mechanical stability from natural resources is a challenging proposition in materials science. Here, we report the scalable synthesis of hybrid collagen scaffolds using collagen extracted from leather industry wastes and sago starch derived from agro-industry. The hybrid scaffolds were incorporated with TiO nanoparticles and cross-linked with oxidized sago starch.

Melatonin in functionalized biomimetic constructs promotes rapid tissue regeneration in Wistar albino rats.

The development of hybrid scaffolds mimicking the extracellular matrix with bioactive factors has great potential to regenerate tissues in tissue engineering and wound-healing applications. Herein, poly(dialdehyde) gum acacia was synthesized by the selective oxidation of gum acacia and was blended with collagen and melatonin to fabricate biomimetic hybrid scaffolds. The inclusion of poly(dialdehyde) gum acacia improved the stability of collagen and immobilized the melatonin in the hybrid scaffolds.

Highly biocompatible collagen-Delonix regia seed polysaccharide hybrid scaffolds for antimicrobial wound dressing.

Biomaterials based entirely on biological resources are ideal for tissue engineering applications. Here we report the preparation of hybrid collagen scaffolds comprising gulmohar seed polysaccharide (GSP) and cinnamon bark extract as cross-linking agent. (1)H NMR spectrum of GSP confirms the presence of galactose and mannose in the ratio of 1:1.

Biomimetic hybrid porous scaffolds immobilized with platelet derived growth factor-BB promote cellularization and vascularization in tissue engineering.

Development of hybrid scaffolds with synergistic combination of growth factor is a promising approach to promote early in vivo wound repair and tissue regeneration. Here, we show the rapid wound healing in Wistar albino rats using biomimetic collagen-poly(dialdehyde) guar gum based hybrid porous scaffolds covalently immobilized with platelet derived growth factor-BB. The immobilized platelet derived growth factor in the hybrid scaffolds not only enhance the total protein, collagen, hexosamine, and uronic acid contents in the granulation tissue but also provide stronger tissues.

Collagen-poly(dialdehyde) guar gum based porous 3D scaffolds immobilized with growth factor for tissue engineering applications.

Here we report the preparation of collagen-poly(dialdehyde) guar gum based hybrid functionalized scaffolds covalently immobilized with platelet derived growth factor - BB for tissue engineering applications. Poly(dialdehyde) guar gum was synthesized from selective oxidation of guar gum using sodium periodate. The synthesized poly(dialdehyde) guar gum not only promotes crosslinking of collagen but also immobilizes the platelet derived growth factor through imine bonds.