Combined effects of vitamin D3 and dioxopiperidinamide derivative on lipid homeostasis, inflammatory pathways, and redox imbalance in non-alcoholic fatty liver disease in vivo zebrafish model.

Liver damage and metabolic dysfunctions, the defining features of non-alcoholic fatty liver disease (NAFLD), are marked by inflammation, oxidative stress, and excessive hepatic fat accumulation. The current therapeutic approaches for NAFLD are limited, necessitating exploring novel treatment strategies. Dioxopiperidinamide derivatives, particularly DOPA-33, have shown effective anti-inflammatory and antioxidant properties, potentially offering therapeutic benefits against NAFLD.

Toxicity and therapeutic property of dioxopiperidin derivative SKT40 demonstrated in-vivo zebrafish model due to inflammatory bowel disease.

Inflammatory bowel disease (IBD) encompasses chronic disorders that cause severe inflammation in the digestive tract. This study evaluates (E)-3-(3,4-dichlorophenyl)-N-(2,6-dioxopiperidin-3-yl) acrylamide (named SKT40), a derivative of dioxopiperidinamide, as a potential novel treatment for IBD. The pharmacological activity of SKT40 indicated positive interactions using network pharmacology and molecular docking in silico.

Assessment of the impact of flood on groundwater hydrochemistry and its suitability for drinking and irrigation in the River Periyar Lower Basin, India.

Owing to the consequences of Anthropocene climate changes, extremes of weather and climate disasters such as heavy precipitation, tropical cyclones, and floods, have strengthened in every region across the globe and are badly affecting the earth system processes. The climate change has a tremendous impact in the Western Ghats, the UNESCO heritage site in India, and has to be studied in detail. Floods are the most common (and among the most deadly) natural disasters bringing heavy destruction in the Western Ghat river basins of India, and the Periyar basin is one among them.

Hydrogeochemical processes controlling the groundwater salinity in the coastal aquifers of Southern Tamil Nadu, India.

The current study identifies groundwater quality issues and investigates the most important geochemical processes that control seawater intrusion using various ionic ratios, hydrochemical facies evolution, and geochemical modelling. Cl/Br ratio is an important indicator to identify the origin of groundwater salinity in coastal aquifers. Nineteen percent of the groundwater samples with Cl/Br ratio similar to that of Standard Mean Ocean Water (SMOW) are affected by seawater intrusion in the study area.

Hydrochemical characterization and groundwater quality in Cauvery deltaic fluvial plains of Southern India.

Groundwater sources are drastically changing in their quantity and quality depending on local and regional level natural and anthropogenic factors, influencing their suitability for drinking and irrigation purposes. The objective of this study is to characterize the hydrochemistry and assess the groundwater quality in the fluvial deltaic plains of Cauvery river basin, Tamil Nadu, India. A total of 50 georeferenced groundwater samples were collected across Needamangalam block of Thiruvarur district and analyzed for major ions and hydrochemical processes.

The Impact of Various Policy Factors Implemented for Controlling the Spread of COVID-19.

More than sixty million cases were affected by the novel corona virus around the world till date. The virus has reached more than 200 countries and more than seven lakh people have lost their lives globally so far. To control the spread of this virus many countries have taken extreme measures but still couldn't control the spread.

Mapping of coastal aquifer vulnerable zone in the south west coast of Kanyakumari, South India, using GIS-based DRASTIC model.

The south west coast of Kanyakumari district in Tamil Nadu, India, is significantly affected by seawater intrusion and diffusion of pollutants into the aquifers due to unregulated beach placer mining and other anthropogenic activities. The present study investigates the vulnerability of the coastal aquifers using Geographic Information System (GIS)-based DRASTIC model. The seven DRASTIC parameters have been analyzed using the statistical equation of this model to demarcate the vulnerable zones for aquifer contamination.

Immunodiagnosis of human lymphatic filariasis: A review.

A monoclonal antibody-based antigen detection system was used to detect the levels of circulating antigen in filarial patients before and after treatment with DEC and in normal individuals living in an area endemic forW. bancrofti infection in Chennai, India. The present study was to show the use of this assay as a means of efficient screening for filariásis in an endemic area where blood was absorbed onto the filter paper by finger prick during day time.