Plasmid DNA Delivery into the Skin via Electroporation with a Depot-Type Electrode.

Non-viral mediated plasmid DNA transfection by electroporation (EP) is an established method for gene transfection. In this study, the usefulness of direct EP at an intradermal () site () with implanted electrodes to achieve a high protein expression level was investigated. In addition, application with various intervals with a low application voltage was also evaluated to confirm its effect on protein expression.