Publications by authors named "Kalin Chakarov"
Article Synopsis
- The study focuses on synthesizing and characterizing new peptide derivatives derived from spinorphin, aiming to explore their potential as therapeutic agents, particularly in treating seizures and possibly other biological activities.
- Various characterization techniques, including scanning electron microscopy and spectroscopic methods, revealed structural changes in the peptides that correlate with their biological effects, particularly in combating seizures.
- The spinorphin derivatives showed notable anticonvulsant activity against multiple phases of seizures, with certain analogs demonstrating effectiveness against drug-resistant epilepsy, indicating their potential for broader therapeutic applications.
Some new hemorphin-4 analogs with structures of Xxx-Pro-Trp-Thr-NH and Tyr-Yyy-Trp-Thr-NH, where Xxx is 2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoic acid or 2-amino-3-(4-dibenzylamino-2,6-dimethylphenyl)propanoic acid, and Yyy is (2S,4S)-4-amino-pyrrolidine-2-carboxylic acid, were synthesized and characterized by electrochemical and spectral analyses. In vivo anticonvulsant and antinociceptive activities of peptide derivatives were studied after intracerebroventricular injection in mice. The therapeutic effects of the modified peptides on seizures and pain in mice were evaluated to provide valuable insights into the potential applications of the novel compounds.
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