Publications by authors named "Kali J Dale"
Purpose: Mutational activation of or (), detected in >90% of uveal melanomas, leads to constitutive activation of oncogenic pathways, including MAPK and YAP. To date, chemo- or pathway-targeted therapies, either alone or in combination, have proven ineffective in the treatment of patients with metastatic uveal melanoma.
Experimental Design: We tested the efficacy of chloroquine or hydroxychloroquine, in combination with MAPK pathway inhibition in -mutated cells and and identified mechanisms of MEK1/2 inhibitor plus chloroquine-induced cytotoxicity.