Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes.

Leukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective selective treatments that could improve the 5-year survival rate. Consequently, the pathophysiological processes within leukemia cells are the focus of critical research.

Hypotensive drugs mitigate the high-sodium diet-induced pro-inflammatory activation of mouse macrophages in vivo.

Nowadays, there is an increasing emphasis on the need to alleviate the chronic inflammatory response to effectively treat hypertension. However, there are still gaps in our understanding on how to achieve this. Therefore, research on interaction of antihypertensive drugs with the immune system is extremely interesting, since their therapeutic effect could partly result from amelioration of hypertension-related inflammation, in which macrophages seem to play a pivotal role.

Ultrasound-Histopathological Presentation of Thyroid and Ovary Lesions in Adolescent Patients with DICER1 Syndrome: Case Reports and Literature Overview.

Background: DICER1, a cancer predisposition syndrome (CPS), seems to escape timely diagnosis in pediatric patients. Case report 1: A 16-year-old female patient was referred to the endocrinology ward due to a large goiter. Her medical history indicated normal sexual maturation, with menarche occurring at 13.

Endothelial dysfunction and risk factors for atherosclerosis in psoriatic arthritis: overview and comparison with rheumatoid arthritis.

Endothelial dysfunction (ED) is defined as an impairment in the vasodilatory, anti-thrombotic, and anti-inflammatory properties of the cells that make up the lining of blood vessels. ED is considered a key step in the development of atherosclerotic cardiovascular disease. The association between ED and systemic inflammatory diseases is well established.

Guilty or not guilty? - False positive results of common medicines in drug tests: review and practical guide.

Drug-abuse detection tests are becoming increasingly commonplace in patient care today and provide a rapid and effective method for identifying illicit substances. Occasionally, they may yield a positive result, indicating the presence of a substance, even though the individual has not consumed the suspected drug what sometimes can significantly impact both medical and legal decisions. The study outlines the substances that can lead to false-positive drug test results for amphetamines, cannabinoids, and benzodiazepines.

Wisdom and wellbeing in polish older adults: the mediating role of forgiveness.

Objectives: Possible correlations between wisdom and wellbeing among older people have been extensively debated in psychology. At the same time, researchers emphasize that the effect of older adults' wisdom on their wellbeing depends on numerous mediators. A review of the literature suggests that forgiveness might be one such variable.

Overreactive macrophages in SARS-CoV-2 infection: The effects of ACEI.

Among various factors influencing the course of SARS-CoV-2 infection in humans, macrophage overactivation is considered the main cause of the cytokine storm that leads to severe complications of COVID-19. Moreover, the increased expression of angiotensin converting enzyme 2 (ACE2), an obligatory entry receptor of the coronavirus, caused by treatment with ACE inhibitors (ACEI) lowered overall confidence in the safety of these drugs. However, analysis of the course of coronavirus infection in patients treated with ACEI does not support these concerns.

Forgive, Let Go, and Stay Well! The Relationship between Forgiveness and Physical and Mental Health in Women and Men: The Mediating Role of Self-Consciousness.

Background: The current study assessed forgiveness (positive forgiveness and reduced unforgiveness), self-consciousness (rumination and reflection), and physical and mental health. The aim of the study was to check if self-consciousness mediates the relationship between dispositional forgiveness and health.

Methods: To address this link, we conducted 2 studies ( = 484 in Study 1 and = 249 in Study 2).

Posttraumatic Growth and Subjective Well-Being in Men and Women after Divorce: The Mediating and Moderating Roles of Self-Esteem.

Prior research has mainly examined non-adaptive responses to divorce, with less attention being paid to positive changes following the adversity of marital dissolution, especially posttraumatic growth and its consequences. The aim of this paper was to analyse the relationship between posttraumatic growth and subjective well-being, as well as the mediating and moderating role of self-esteem in this relationship among divorced men and women. The sample consisted of 209 divorcees (143 females, 66 males) aged 23-80 ( = 41.

Posttraumatic growth and interpersonal forgiveness in persons with physical disabilities.

Purpose/objective: To investigate whether there is a relationship between posttraumatic growth (PTG) and forgiveness in people with physical disabilities, and whether contextual factors moderate the association.

Research Method/design: Two hundred and sixty seven persons with physical disabilities completed Polish versions of three inventories: Posttraumatic Growth Inventory (PTGI), Decision to Forgive Scale (DTFS), and Emotional Forgiveness Scale (EFS). The participants also assessed contextual factors of offenses, such as transgression severity, apology being offered, and quality of the relationship with the offender.

Gender and age differences in forgivingness in Italian and Polish samples.

This study explores gender and age differences in forgivingness using the crosscultural and stress-and-coping perspective. Polish and Italian versions of the Heartland Forgiveness scale (HFS) were used. The sample consisted of 1957 individuals aged 18-80 (61% females and 39% males).

The immunomodulatory effects of antihypertensive therapy: A review.

Hypertension remains the leading preventable risk factor for stroke and coronary artery disease, significantly contributing to all-cause global mortality and predisposing patients to renal and heart failure, as well as peripheral vascular disease. Due to the widespread usage of antihypertensive drugs, global mean blood pressure has remained unchanged or even slightly decreased over the past four decades. However, considering the broad spectrum of mechanisms involved in the action of antihypertensive drugs and the prevalence of their target receptors on immune cells, possible immunomodulatory effects which may exert beneficial effects of lowering blood pressure but also potentially alter immune function should be considered.

Dendritic cells may help differentiate discoid lupus erythematosus alopecia from lichen planopilaris.

Introduction: Primary cicatricial alopecia (PCA) encompasses a heterogeneous group of inflammatory diseases characterized by the replacement of hair follicle structures by fibrous tissue. Discoid lupus erythematosus (DLE) and lichen planopilaris (LPP) are the most common causes of scarring alopecia. The distinction between both entities is often challenging because of significant clinical and histopathological overlap.

Internet Addiction as a Moderator of the Relationship between Cyberhate Severity and Decisional Forgiveness.

(1) Background: Cyberhate is becoming increasingly prevalent, just as Internet addiction. One way to deal with hate speech may be to make a decision to forgive the offence. However, addiction to the Internet, due to cognitive changes caused, can play a role in the making of this decision.

Atrophic papulosis (Köhlmeier-Degos disease) revisited: a cross-sectional study on 105 patients.

Background: Atrophic papulosis is a very rare vascular disease of unknown pathogenesis, mostly described by case reports.

Objective: To assess demographic data and prognosis in patients with atrophic papulosis.

Methods: A single-centre study was performed on a series of 105 patients with atrophic papulosis, diagnosed 2000-2021.

Gender Differences in Forgiveness and its Affective Correlates.

Although women are believed to be more forgiving than men, the results of many studies comparing women with men vary. Moreover, little is known about unique correlates or differential patterns of experiencing forgiveness by gender. In the present study, we compared men and women in terms of their level of dispositional forgiveness and its emotional correlates, namely positive and negative affect, anxiety, and emotional control.

Changes in Corneal Parameters after DMEK Surgery: A Swept-Source Imaging Analysis at 12-Month Follow-Up Time.

Purpose: To assess the time course changes in corneal topographic parameters during the one-year follow-up after Descemet membrane endothelial keratoplasty (DMEK) surgery.

Materials And Methods: Twenty-one patients (24 eyes) who underwent DMEK surgery were evaluated. Best corrected visual acuity (BCVA), endothelial cell count (ECC), central corneal thickness (CCT), mean keratometry (MK), mean astigmatism (MA), astigmatism asymmetry (AA), and higher-order aberration (HOA) were assessed at baseline and 1, 3, 6 and 12 months after the surgery using CASIA2 anterior segment swept-source OCT (Tomey, Japan).

Metabolic Disorders/Obesity Is a Primary Risk Factor in Hidradenitis Suppurativa: An Immunohistochemical Real-World Approach.

Background: Hidradenitis suppurativa (HS) is an inflammatory, potentially scarring disease of the hair follicle, affecting the apocrine gland-bearing skin areas. The major comorbid disorders associated with the occurrence or the aggravation of the disease are obesity and smoking. Numerous efforts to dissociate these factors led to controversial results.