[Therapeutic targets of adolescent depression with attenuated symptoms of schizophrenia].

Objective: Identification of therapeutic targets in the treatment of adolescent depression with attenuated symptoms of schizophrenia and assessment of the effectiveness of therapeutic interventions.

Material And Methods: One hundred and twenty-three patients (mean age 19.6±2.

[Evolution of views on the phenomenon of spiritual possession within the framework of psychiatric pathology (psychopathological, transnosological and transcultural aspects)].

The spiritual possession phenomenon (SPP), is a complex transnosological, transcultural syndrome, which is based on the patients' perception that some spiritual entity (spirit, demon, jinn, shaitan, «ikotka», dybbuk, Buddha, etc.) is influencing or possessing them. Modern classifications of diseases, aimed at expanding our ideas about the distinction between the norm and pathology of mental disorders, do not contribute to a clear psychopathological differentiation of SPP, the determination of its nosological affiliation and the choice of appropriate therapeutic tactics for these conditions.

[The relationship between inflammatory markers, fatigue, and effort-based decision-making in patients at clinical high risk for psychosis].

Objective: To evaluate the associations between peripheral levels of inflammatory markers and willingness to exert effort in individuals at clinical high risk for psychosis (CHR-P) and a role of fatigue as a mediator of these associations.

Material And Methods: Forty-nine young men admitted for a depressive episode, who met the criteria for CHR-P, had pre-treatment blood tests to determine levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukins IL-6, IL-8 and IL-10. After treatment and normalization of their condition, they completed the EEfRT task of willingness to exert physical effort to receive monetary reward and filled out the Fatigue Assessment Scale (FAS-10).

[Transcranial magnetic stimulation (rTMS) in the treatment of depressive disorders].

Objective: To conduct a comparative assessment of the clinical outcome and tolerability of rTMS using different stimulation protocols, as well as to determine the dynamics of neurophysiological markers of the functional state of the brain.

Material And Methods: Twenty-eight patients (mean age 23.5±4.

Resting-state functional connectivity correlates of brain structural aging in schizophrenia.

A large body of research has shown that schizophrenia patients demonstrate increased brain structural aging. Although this process may be coupled with aberrant changes in intrinsic functional architecture of the brain, they remain understudied. We hypothesized that there are brain regions whose whole-brain functional connectivity at rest is differently associated with brain structural aging in schizophrenia patients compared to healthy controls.

[Willingness to expend effort for rewards in individuals at clinical high-risk for psychosis: a relationship with the severity and stability of negative symptoms].

Objective: To identify the deficit in willingness to expend effort and its association with negative symptoms in the high-risk for psychosis (CHR) group.

Material And Methods: The study included young men: 45 patients, who met CHR criteria and were treated for a depressive episode, and 15 controls. All subjects completed a modified version of the Effort Expenditure for Rewards Task (EEfRT).

[History of the development of domestic psychiatry: the period 1940-1980].

The article briefly presents an analysis of the development of domestic psychiatry (with an emphasis on research in the field of psychopathology and nosology) from the post-war period (the Great Patriotic War) to the era of "perestroika". With the founding of the Institute of Psychiatry of the USSR Academy of Medical Sciences under the leadership of V.A.

[Application of the biofeedback method in the therapy of depression].

In order to systematize the modern literature data on the effectiveness of biofeedback in the treatment of patients with depressive disorders, clinical efficacy and prospects for use in psychiatric practice, publications in the MEDLINE / PubMed, eLibrary databases from 2013 to 2023, as well as relevant references in the reference lists of the analyzed articles, were selected by the keywords «biofeedback», «depression», «depression therapy», «electroencephalogram», «non-drug treatments for depression». The analysis of data has shown that the biofeedback method demonstrates a certain therapeutic potential in the treatment of depression. It can be used to augment therapy in case of insufficient therapeutic effect, with low patient compliance, as well as poor tolerability of psychopharmacotherapy and in the presence of residual symptoms after pharmacological treatment.

[Psychopathology of depressive-delusional states with religious content].

Objective: Identification of psychopathological characteristics of depressive-delusional states with religious content, development of a typology, determination of formation features, nosological assessment.

Material And Methods: A total of 79 patients (47 female, 32 male, mean age 27±6.5 years) with depressive-delusional states with religious content within the affective and schizophrenia spectrum disorders were studied.

[Existential youth depressions].

Objective: To determine the clinical and psychopathological features of existential depression in youth.

Material And Methods: 53 male patients (16-25 years old) with diagnosis F31.3, F31.

[Features of inflammatory reactions in patients with juvenile depression with a clinically high risk of psychosis].

Objective: To determine the levels of pro-inflammatory and anti-inflammatory cytokines and inflammatory markers such as C-reactive protein, leukocyte elastase, α1-proteinase inhibitor, autoantibodies to neuroantigens in the blood of patients with adolescent depression with clinical high risk for psychosis (CHR-P) and to study the relation of these biological markers to the features of psychopathological symptomatology of the patients.

Material And Methods: Eighty young adults, aged 16-24 years, with the first depressive episode (F32.1-2, F32.

[Juvenile depression as at-risk state for psychotic disorders].

Objective: To establish the risk of psychotic disorders in juvenile depression and to study the role of negative symptoms in its formation.

Material And Methods: Seventy-four in-patients (19.6±2.

Executive control of language in schizophrenia patients with history of auditory verbal hallucinations: A neuropsychological and resting-state fMRI study.

Background: As demonstrated by a plethora of studies, compromised executive functions (EF) and language are implicated in mechanisms of auditory verbal hallucinations (AVH), but the contribution of their interaction to AVH remains unclear. We hypothesized that schizophrenia patients with history of AVH (AVHh+) vs. without history of AVH (AVHh-) have a specific deficit of executive control of language and alterations in functional connectivity (FC) between the brain regions involved in EF and language, and these neuropsychological and neurophysiological traits are associated with each other.

[Augmentation therapy of resistant schizophrenia with rhythmic transcranial magnetic stimulation].

Objective: To identify the clinical efficacy of rhythmic transcranial magnetic stimulation (rTMS) in resistant schizophrenia.

Material And Methods: The study included 44 male patients with resistant schizophrenia, divided into 4 groups: with depressive (group 1; =11, 25.0%), with hallucinatory (group 2; =12, 27.

[Structural features of the brain in individuals with youth depression at a clinical risk for psychosis].

Objective: To establish the structural features of the brain (cortical and subcortical) in depressive patients at clinical risk for psychosis.

Material And Methods: Nineteen right-handed male patients with youth depression, who were assessed for high risk of psychotic manifestation, and 20 healthy controls underwent MRI and clinical examination. T1-weighted images were processed in FreeSurfer 7.

[Therapeutic drug monitoring of antipsychotic drugs in routine psychiatric practice].

Objective: To evaluate the relationship between daily doses of antipsychotic drugs, their serum concentrations, and characteristics of patients treated for schizophrenia or schizophreniform disorder in day-to-day clinical practice.

Material And Methods: A total of 187 patients were included in the study, 77 (41.1%) patients were on monotherapy, and 110 (58.

[Borderline personality disorder in young adults: features of psychopathology and patterns of course].

Objective: To identify the psychopathological features of borderline personality disorder (BPD) in adolescence, determine the trajectory of its further course, and develop criteria for differential diagnosis.

Material And Methods: Clinical/psychopathological and psychometric methods were used to study 143 patients. The patients were divided into two groups: a clinical group - 73 patients, who were inpatients or outpatients in the clinical departments of the Mental Health Research Center (MHRC) in 2019-2022, and a follow-up group - 70 patients who were inpatients or outpatients in the MHRC clinic in 2006-2010.

[Attenuated negative symptoms in the structure of youth depression].

Objective: To detect negative symptoms in adolescent depression, to determine their psychopathological structure and predictive significance.

Material And Methods: Seventy-one young in-patients (average age 19.5±2.

The Effect of Untreated Illness in Youth Depression: A Cross-Sectional Study.

Background: The existing research has mainly focused on exploring how the duration of untreated psychosis effects the further course of the disease. By contrast, the duration of an untreated illness (DUI) in youth depression and its impact on the further course of the disease has remained scarcely investigated.

Aim: The current study aims to determine how the duration of untreated illness affects the severity of the symptoms during the first depressive episode and the degree to which the symptoms are reduced after treatment.

[Premorbid features of youth depression patients with attenuated schizophrenic symptoms].

Objective: To establish the premorbid features in youth depression patients with attenuated symptoms of schizophrenia (ASS) and in a comparison group, with an analysis of the course of age crises, signs of personality disorders, level of premorbid functioning and their relationship with the level of functioning after five-year follow-up.

Material And Methods: Two hundred and nineteen youth depression patients with ASS (according to ICD-10: F32.1, F32.