PARP1 promotes tumor proliferation in lenalidomide-resistant multiple myeloma via the downregulation of microRNA-192-5p-AKT signaling.

Background: Lenalidomide-based therapies are recommended as first-line treatment for multiple myeloma (MM) patients, regardless of the transplant eligibility. Resistance to lenalidomide is a clinical problem that urgently needs to be addressed. The expression of poly(ADP-ribose) polymerase 1 (PARP1) is abnormally high in a variety of tumor tissues including MM.

Nanostructured electroless Ni deposited SnO for solar hydrogen production.

Herein, Ni-decorated SnO (Ni@SnO) nanostructures have been synthesized using SnO as a matrix a simple electroless deposition method for the generation of hydrogen, a potent near-future fuel. XRD analysis confirmed the generation of rutile SnO in Ni@SnO. FESEM and FETEM imaging exhibited the formation of SnO nanoparticles with a size of 10-50 nm, which are deposited with Ni nanoparticles (5-7 nm) and intermittent films (thickness 1-2 nm).

Microstructure tuned NaV(PO)@C electrodes toward ultra-long-life sodium-ion batteries.

Sodium-ion batteries (SIBs) are emerging as the best replacement for Li-ion batteries. In this regard, research on developing a reliable cathode material for SIBs is burgeoning. Rhombohedral NaV(PO) (NVP), is a typical sodium super ionic conductor (NASICON) type material having prominent usage as a cathode material for SIBs.

Mapping the cancer surface proteome in search of target antigens for immunotherapy.

Immune-based therapeutic interventions recognizing proteins localized on the cell surface of cancer cells are emerging as a promising cancer treatment. Antibody-based therapies and engineered T cells are now approved by the Food and Drug Administration to treat some malignancies. These therapies utilize a few cell surface proteins highly expressed on cancer cells to release the negative regulation of immune activation that limits antitumor responses (e.

Solid state engineering of BiS/rGO nanostrips: an excellent electrode material for energy storage applications.

The study presents a novel, one-pot, and scalable solid-state reaction scheme to prepare bismuth sulphide (BiS)-reduced graphene oxide (rGO) nanocomposites using bismuth oxide (BiO), thiourea (TU), and graphene oxide (GO) as starting materials for energy storage applications. The impact of GO loading concentration on the electrochemical performance of the nanocomposites was investigated. The reaction follows a diffusion substitution pathway, gradually transforming BiO powder into BiS nanostrips, concurrently converting GO into rGO.

Living will: Todays thoughts and actions.

Introduction: The word "Euthanasia" relates to two different words from the Greek language "Eu which indicates good and Thanatosis which indicates death", suggesting a "satisfactory Death" or "easy and painless Death" The phrase "mercy killing" has become associated with this meaning. It comprises inflicting painless death on a person suffering from an incurable and dreadful illness. It's the practice of terminating a person's life by administering a lethal injection or ceasing medical treatment.

Comparative Evaluation of the Effectiveness of and Chlorhexidine in Full-mouth Disinfection Treatment of Periodontitis in Type 2 Diabetes Patients.

Aim: To evaluate and compare the efficacy of and chlorhexidine (CHX) in the treatment of stages II and III periodontitis with one-stage complete mouth disinfection in type 2 diabetes mellitus (DM) patients.

Materials And Methods: A total of 24 type 2 diabetic subjects with either stage II or stage III periodontitis were randomly divided into test and control groups with 12 patients in each group. For control group, full-mouth disinfection (FMD) was done using CHX and for test group, FMD was done using .

synthesis of g-CN/TiCT nano-heterostructures for enhanced photocatalytic H generation water splitting.

Herein, we demonstrated the synthesis of g-CN/TiCT nano-heterostructures for hydrogen generation under UV visible light irradiation. The formation of the g-CN/TiCT nano-heterostructures was confirmed powder X-ray diffraction and supported by XPS. The FE-SEM images indicated the formation of layered structures of MXene and g-CN.

Factors Influencing Parents' Decision in Choosing a Pediatric Dentist.

Introduction Pediatric dentists support children's dental health while also providing parents with health education and information. Parents are guardians of their children's oral health, as their knowledge, beliefs, also attitude about oral health can influence early childhood oral health directly or indirectly. Recognizing parenting practices on early childhood oral health is essential for developing effective prevention and treatment strategies for the child, because parents' health attitudes, behavior, and their children's dental health are usually influenced directly or indirectly by their practice.

Engineering of Solar Energy Harvesting Tb-Ion-Doped CdS Quantum Dot Glasses for Photodissociation of Hydrogen Sulfide.

The photocatalytic properties of CdS quantum dots (Q-dots) and Tb-doped CdS Q-dots dispersed in a borosilicate glass matrix were investigated for the photodissociation of hydrogen sulfide (HS) into hydrogen (H) gas and elemental sulfur (S). The Q-dot-containing glass samples were fabricated using the conventional melt-quench method and isothermal annealing between 550 and 600 °C for 6 h for controlling the growth of CdS and Tb-ion-doped CdS Q-dots. The structure, electronic band gap, and spectroscopic properties of the Q-dots formed in the glass matrix after annealing were analyzed using Raman and UV-visible spectroscopies, X-ray powder diffraction, and transmission electron microscopy.

Highly Stable MWCNT@NVP Composite as a Cathode Material for Na-Ion Batteries.

A 3D framework with Nasicon structured polyanionic NaV(PO) (NVP) has been emphasized as a leading cathode material for sodium-ion batteries (SIBs) due to its high working voltage plateau, structural stability, and good rate performance. Herein, pristine NVP and MWCNT@NVP composite synthesized via a facile solid-state method are examined and compared as cathode materials for Na-ion batteries. The morphological study confirms the uniform distribution of MWCNTs in the pristine NVP structure.

The synthesis and super capacitive characterization of microwave-assisted highly crystalline α-FeO/FeO nanoheterostructures.

A facile microwave-assisted solvothermal process for the synthesis of narrow-size distributed α-FeO, α-FeO/FeO, and FeO nanostructures was demonstrated using PVP as a surfactant. During the reaction, the influence of the reaction media, such as the mixture of ethylene glycol and water on the formation of α-FeO, α-FeO/FeO, and FeO was systematically studied. Interestingly, pure aqueous medicated solvothermal reaction conferred phase pure rhombohedral FeO (hematite) and linearly upsurging the formation of cubic FeO (magnetite) with the increasing concentration of EG and further, in pure EG, it deliberated cubic FeO.

Electroless Ni plated nanostructured TiO as a photocatalyst for solar hydrogen production.

Herein, we have demonstrated a facile electroless Ni coated nanostructured TiO photocatalyst for the first time. More significantly the photocatalytic water splitting shows excellent performance for hydrogen production which is hitherto unattempted. The structural study exhibits majorly the anatase phase along with the minor rutile phase of TiO.

Evaluation of PRF Membrane with Coronally Advanced Flap with and without Vertical Releasing Incisions for the Treatment of Gingival Recessions.

Aim: The aim of the current study was to compare the esthetic results for subjects with Miller Class I and II gingival recession (GR) abnormalities using platelet-rich fibrin (PRF) membrane with coronal advanced flaps (CAFs) with and without vertical releasing incisions (VRIs; the envelope-type flap and the flap with VRIs).

Materials And Methods: Seven defects from each of the test and control groups made up of fourteen defects total. In the test group, PRF + CAF was performed without VRI, while in the control group, VRI was used.

Ni loaded SnS hexagonal nanosheets for photocatalytic hydrogen generation water splitting.

Herein we have prepared the Ni-decorated SnS nanosheets with varying concentrations of Ni from 1 to 10 mol% (1, 2.5, 5, and 10 mol%) and studied their various physicochemical and photocatalytic properties. The chemical reduction technique was utilized to load the Ni nanoparticles on SnS nanosheets.

GenSLMs: Genome-scale language models reveal SARS-CoV-2 evolutionary dynamics.

We seek to transform how new and emergent variants of pandemic-causing viruses, specifically SARS-CoV-2, are identified and classified. By adapting large language models (LLMs) for genomic data, we build genome-scale language models (GenSLMs) which can learn the evolutionary landscape of SARS-CoV-2 genomes. By pre-training on over 110 million prokaryotic gene sequences and fine-tuning a SARS-CoV-2-specific model on 1.

A blind randomized controlled pilot trial on recombinant human bone morphogenetic protein-2 in combination with a bioresorbable membrane on periodontal regeneration in mandibular molar furcation defects.

Objectives: In preparation of a definitive randomized clinical trial (RCT), the current parallel-grouped triple-blind pilot RCT assessed the efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) with polylactic acid/polyglycolic acid (PLA/PGA) membrane for improvement of periodontal tissue regeneration in Class II furcation type defects.

Method And Materials: With the present single-center investigation, 24 patients/24 mandibular molars revealing Class II furcation lesions with involved buccal surfaces were randomly allocated and treated surgically, using either a PLA/PGA membrane alone (control, n = 12) or in combination with rhBMP-2 (n = 12). Assessors, participants, and the statistician were blinded to the treatment groups.

Implementation of Low-Level Laser Therapy in Dentistry: A Review.

A type of light therapy known as low-level laser therapy (LLLT) uses only one wavelength of light. Low-level lasers (LLL) do not have a warming effect on the tissues; instead, they have an effect called photobiostimulation. LLL do not evaporate the tissue.

Biofilm inhibition in Candida albicans with biogenic hierarchical zinc-oxide nanoparticles.

The present study demonstrates lignin (L), fragments of lignin (FL), and oxidized fragmented lignin (OFL) as templates for the synthesis of zinc oxide nanoparticles (ZnO NPs) viz., lignin-ZnO (L-ZnO), hierarchical FL-ZnO, and OFL-ZnO NPs. The X-ray diffraction patterns confirmed the formation of phase pure ZnO NPs with a hexagonal wurtzite structure.

Efficient solar light-driven hydrogen generation using an SnO nanoflake/graphene nanoheterostructure.

Herein, we report SnO and SnO nanoflake/graphene for photocatalytic hydrogen generation from HO and HS under natural "sunlight" irradiation. The SnO/graphene composites were prepared by a simple hydrothermal method at relatively low temperatures (150 °C). The incorporation of graphene in SnO exhibits remarkable improvement in solar light absorption, with improved photoinduced charge separation due to formation of the heterostructure.

A nanostructured SnO/Ni/CNT composite as an anode for Li ion batteries.

A SnO/Ni/CNT nanocomposite was synthesized using a simple one-step hydrothermal method followed by calcination. A structural study XRD shows that the tetragonal rutile structure of SnO is maintained. Further, X-ray photoelectron spectroscopy (XPS) and Raman studies confirm the existence of SnO along with CNTs and Ni nanoparticles.

Unique hierarchical SiO@ZnInS marigold flower like nanoheterostructure for solar hydrogen production.

The novel marigold flower like SiO@ZnInS nano-heterostructure was fabricated using an hydrothermal method. The nanoheterostructure exhibits hexagonal structure with marigold flower like morphology. The porous marigold flower assembly was constructed using ultrathin nanosheets.

Polyaniline-wrapped MnMoO as an active catalyst for hydrogen production by electrochemical water splitting.

Developing efficient, low-cost, and environment-friendly electrocatalysts for hydrogen generation is critical for lowering energy usage in electrochemical water splitting. Moreover, for commercialization, fabricating cost-efficient, earth-abundant electrocatalysts with superior characteristics is of urgent need. Towards this endeavor, we report the synthesis of PANI-MnMoO nanocomposites using a hydrothermal approach and an polymerization method with various concentrations of MnMoO.