Impact of TNF haplotypes in the physical course of acne vulgaris.

Background: The role of single-nucleotide polymorphisms (SNPs) of the TNF gene in acne vulgaris remains controversial.

Methods: Genomic DNA was isolated from 185 patients with acne vulgaris and 165 healthy controls. SNPs at positions -376, -308 and -238 of the promoter region of TNF were defined.

Diffuse Goiter and Severe Hypothyroidism due to Metastasis to the Thyroid.

Despite the fact that the thyroid is a highly vascularized organ, clinically significant metastatic spread to the thyroid is considered uncommon. Hypothyroidism due to these metastases seldom occurs. A 68-year-old female patient came to our department because of rapid enlargement of the lower anterior part of the neck, which developed within 2 months.

Hematologic toxicity in patients treated with sunitinib for advanced thyroid cancer.

Background: Although thyroid carcinoma is more indolent than other solid tumors, distant metastatic disease due to differentiated thyroid carcinoma (DTC) and medullary thyroid carcinoma (MTC) is often refractory to treatment and thus a challenge for clinicians. New agents such as tyrosine kinases inhibitors have been introduced recently for therapy of metastatic thyroid cancer but they have toxic side effects as well as therapeutic benefits. The objective of this study was to determine the hematologic toxicities of sunitinib, a multiple receptor tyrosine kinases inhibitor, when used to treat progressive, advanced DTC and MTC.

Exophytic and ulcerated local recurrence of papillary thyroid carcinoma with spectacular response to external beam radiotherapy.

A 60-year-old female patient with a history of multifocal papillary thyroid carcinoma was referred to the endocrinology clinic for an exophytic and ulcerated lesion at the right base of the neck. Twelve years earlier she had undergone a total thyroidectomy for multinodular goiter. Four years after the total thyroidectomy she had a lymph node dissection of the neck and was then treated twice with 100 mCi 131I.