Antimicrobial resistance pattern of Klebsiella isolated from various clinical samples in Ethiopia: a systematic review and meta-analysis.

Background: The burden of Klebsiella drug resistance to antimicrobials is a major public health concern worldwide; particularly the problem is severe in developing countries including Ethiopia. Therefore, the aim of this systematic review and meta-analysis is to establish the pooled estimate of Klebsiella drug resistance; and antimicrobial-specific resistance pattern among Klebsiella clinical isoaltes in Ethiopia.

Methods: Articles were searched from PubMed, Google Scholar, and Science direct and grey literature from 2009 to 2019.

Adequacy of Cancer-Related Pain Treatments and Factors Affecting Proper Management in Ayder Comprehensive Specialized Hospital, Mekelle, Ethiopia.

Background: Cancer-related pain (CRP) is a major problem with a potential negative impact on quality of life of the patients and their caregivers.

Purpose: To assess the adequacy of cancer-related pain management in Ayder Comprehensive Specialized Hospital (ACSH). .

In vitro Antioxidant and in vivo Hepatoprotective Activities of Root Bark Extract and Solvent Fractions of Hochst. Ex Del. () on Paracetamol-Induced Liver Damage in Mice.

Background: Liver disease is a major public health threat, particularly in developing countries. Several medicinal plants and formulations have been claimed to have liver protective activities. The present study aimed to evaluate in vitro antioxidant and in vivo hepatoprotective activities of root bark extracts of

Methods: Free radical scavenging activity of crude extract and solvent fractions of the plant was conducted using the DPPH assay method.

Evaluation of in-vivo antidiarrhoeal and in-vitro antibacterial activities of the root extract of Brucea antidysenterica J. F. Mill (Simaroubaceae).

Background: Diarrhoea has been the major cause of death especially in children of developing countries. Brucea antidysenterica is one of the several medicinal plants used traditionally for the treatment of diarrhoea in Ethiopia. Hence, the present study was undertaken to investigate the antidiarrhoeal and antibacterial activities of the root extract of B.

Evaluation of Antidiabetic Effect of Ethanolic Leaves Extract of Lam. (Lamiaceae) in Streptozotocin-Induced Diabetic Mice.

Background: has been used traditionally for treatment of different ailments including diabetes mellitus although it lacks scientific evidence. Thus, the present study was aimed at evaluating the antidiabetic effect of in streptozotocin (STZ)-induced diabetic mice.

Methods: The antidiabetic activity of hydro-ethanolic (30:70) leaf extract of was evaluated in STZ (45 mg/kg)-induced diabetic and normal mice.

L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses.

The seed of () has been used in different civilization around the world for centuries to treat various animal and human ailments. So far, numerous studies demonstrated the seed of and its main active constituent, thymoquinone, to be medicinally very effective against various illnesses including different chronic illness: neurological and mental illness, cardiovascular disorders, cancer, diabetes, inflammatory conditions, and infertility as well as various infectious diseases due to bacterial, fungal, parasitic, and viral infections. In spite of limited studies conducted so far, the promising efficacy of against HIV/AIDS can be explored as an alternative option for the treatment of this pandemic disease after substantiating its full therapeutic efficacy.

Repurposing of the β-Lactam Antibiotic, Ceftriaxone for Neurological Disorders: A Review.

To date, there is no cure or disease-modifying agents available for most well-known neurological disorders. Current therapy is typically focused on relieving symptoms and supportive care in improving the quality of life of affected patients. Furthermore, the traditional drug discovery technique is more challenging, particularly for neurological disorders.

Antimicrobial resistance patterns of uropathogens isolated between 2012 and 2017 from a tertiary hospital in Northern Ethiopia.

Objectives: Urinary tract infections (UTIs) are one of the most common infections in humans. Studies have shown that antibiotics for UTIs are usually prescribed empirically before the results of urine culture are available. The aim of the study was to assess the antimicrobial resistance patterns of bacteria isolated from urine samples over 6 years in Ayder Comprehensive Specialized Hospital (ACSH), in Mekelle, Northern Ethiopia.

Wound Healing and Anti-Inflammatory Activities of Leaf Latex of Baker (Xanthorrhoeaceae).

Background: Baker (Xanthorrhoeaceae) is one of the species widely distributed in Ethiopia. The leaf latex of the plant is used for treatment of wounds, inflammation, and other multiple ailments in Ethiopian traditional medicine.

Purpose: The aim of this study was to evaluate wound healing and anti-inflammatory activities of the leaf latex of in mice.

Drug Resistance Patterns of in Ethiopia: A Meta-Analysis.

Background: Antimicrobial drug resistance is a global threat for treatment of infectious diseases and costs life and money and threatens health delivery system's effectiveness. The resistance of to frequently utilized antimicrobial drugs is becoming a major challenge in Ethiopia. However, there is no inclusive countrywide study.

Targeting Renin-Angiotensin System Against Alzheimer's Disease.

Renin Angiotensin System (RAS) is a hormonal system that regulates blood pressure and fluid balance through a coordinated action of renal, cardiovascular, and central nervous systems. In addition to its hemodynamic regulatory role, RAS involves in many brain activities, including memory acquisition and consolidation. This review has summarized the involvement of RAS in the pathology of Alzheimer's disease (AD), and the outcomes of treatment with RAS inhibitors.

Neuroactive Steroids: Receptor Interactions and Responses.

Neuroactive steroids (NASs) are naturally occurring steroids, which are synthesized centrally as from cholesterol and are classified as pregnane, androstane, and sulfated neurosteroids (NSs). NASs modulate many processes interacting with gamma-aminobutyric acid (GABA), -methyl-d-aspartate, serotonin, voltage-gated calcium channels, voltage-dependent anion channels, α-adrenoreceptors, X-receptors of the liver, transient receptor potential channels, microtubule-associated protein 2, neurotrophin nerve growth factor, and σ1 receptors. Among these, NSs (especially allopregnanolone) have high potency and extensive GABA-A receptors and hence demonstrate anticonvulsant, anesthetic, central cytoprotectant, and baroreflex inhibitory effects.