Effect of solid lipid nanoparticles loaded with valproate and metformin on pentylenetetrazole-induced epilepsy in rats.

Valproate is a first-line therapy for epilepsy. It enhances GABA-mediated inhibition by increasing GABA synthetase enzyme activity. However, it causes hepatotoxicity.

Tragia involucrata Leaf-Mediated ZnO NPs: Biomedical Applications, Ointment Formulation and Electrochemical Studies.

Zinc oxide (ZnO) NPs, owing to their broad biomedical applications, have recently attracted the scientific community with incredible interest as therapeutic agents. So, the present study aims at preparation of ZnO NPs, using Tragia involucrata leaf extract and exploring their capability as antioxidant, anticancer and anti-inflammatory agents. Besides, the ointment formulation and electrochemical studies were also carried out in this work.

Antihyperglycemic and antihyperlipidemic activities of wild musk melon ( var. ) in streptozotocin-nicotinamide induced diabetic rats.

Objective: Wild musk melon ( var, CMA) is one of the edible plants form Tamil Nadu. Traditionally, this plant was used as diabetic diet (leaves of CMA with leaves), but there is no scientific report on antidiabetic action of this plant material. Hence, the current research work was designed to evaluate the antihyperglycemic and antihyperlipidemic effect of hydroalcoholic extract of CMA leaves (HALEC) in streptozotocin (STZ)-nicotinamide (NIC)-induced diabetic rats.

Barringtonia acutangula improves the biochemical parameters in diabetic rats.

Aim: This study was aimed at evaluating the anti-diabetic activity of the ethanol and aqueous extracts of the leaf material of Barringtonia acutangula in a diabetic animal model.

Methods: The ethanolic and aqueous extracts (250 and 500 mg·kg(-1) body weight) of the leaves of B. acutangula were assessed for antidiabetic activity in a streptozotocin (STZ)-induced diabetes animal model following 21 days of treatment.

Anti-ulcer activity of Ficus religiosa leaf ethanolic extract.

Objective: To evaluate the anti-ulcer activity and acute toxicity of Ficus religiosa (F. religiosa) leaf ethanolic extract in animal models.

Methods: Anti-ulcer activity of F.

Effect of Biophytum sensitivum on streptozotocin and nicotinamide-induced diabetic rats.

Objective: To investigate the effect of aqueous solution of Biophytum sensitivum leaf extract (BSEt) on normal and streptozotocin (STZ)-nicotinamide-induced diabetic rats.

Methods: Diabetes was induced in adult male Wistar rats by the administration of STZ-nicotinamide (40, 110 mg/kg b.w.

Poly(D,L-lactic-co-glycolic acid) nanoencapsulation reduces Erlotinib-induced subacute toxicity in rat.

Erlotinib-HCl is a quinazoline derivative used as a drug in the therapy of non-small-cell lung cancer. The present study was conducted to compare the subacute toxicity induced by Erlotinib-HCl delivered to rats as nanoparticles and as free drug. Wistar rats were orally administered with a daily dosage of 200 mg kg(-1) Erlotinib-HCl either as free drug or as Poly(D,L-lactic-co-glycolic acid) (PLGA) encapsulated nanoparticles.