Formulation and Evaluation of a Transferosomal Gel of Famciclovir for Transdermal Use.

Objectives: Famciclovir, the drug of choice for cold sores and recurrent genital herpes, has poor oral bioavailability and is associated with numerous side effects. The study aimed to explore the possibility of transdermal application of famciclovir through a transferosome-loaded gelling system to localize the drug at the site of application with improved penetrability, therapeutic effects, and comfort.

Materials And Methods: Transferosomes of famciclovir were prepared using tween 80, phospholipid, and cholesterol.