Publications by authors named "Kala E Hickey"
Interval colorectal cancers (I-CRCs) arise during the interval time period between scheduled colonoscopies. Predicting which patients are at risk of I-CRCs remains an elusive undertaking, but evidence would suggest that most I-CRCs arise from lesions missed on index endoscopy. The procedural factors that lead to missed lesions are numerous and lack consensus in the literature.
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- - The study investigates whether a synthetic amino acid sequence similar to the heparin binding domain (HBD) of human hepatic lipase (hHL) can effectively displace hHL from cell surfaces.
- - Researchers created a recombinant protein with the specific HBD and found that it successfully removed hHL from HEK-293 cells, while a scrambled peptide did not have this effect.
- - While the HBD peptide was largely unstructured, its interaction with heparin showed potential changes in structure, indicating that mimetic peptides could be useful for targeting cell surface lipases.