Publications by authors named "Kakeda S"

Article Synopsis
  • A study investigated the relationship between hemoglobin levels and brain volume in a large group of elderly participants using MRI scans.
  • It involved 2153 participants, mainly aged around 69, and found that lower hemoglobin levels were linked to reduced total white matter volume, especially in younger individuals.
  • The study concluded that low hemoglobin levels can negatively impact white matter volume as people age, but didn't find significant effects on gray matter or hippocampal volumes.
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Background And Purpose: Parkinson disease is a prevalent disease, with olfactory dysfunction recognized as an early nonmotor manifestation. It is sometimes difficult to differentiate Parkinson disease from atypical parkinsonism using conventional MR imaging and motor symptoms. It is also known that olfactory loss occurs to a lesser extent or is absent in atypical parkinsonism.

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Purpose: This study aims to measure job satisfaction among interventional radiology physicians in Japan and analyze the factors affecting job satisfaction.

Material And Methods: A web-based survey was conducted among the members of the Japanese Society of Interventional Radiology between October and December 2021. Participants were questioned regarding their job satisfaction, workplace, work status, and demographic information.

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Background: We investigated volumetric alterations in the bilateral choroid plexus (ChP) and brain ventricles of patients during their first episode of major depressive disorder (MDD) prior to antidepressant treatment.

Methods: Seventy-one first-episode drug-naïve patients with MDD and seventy-four healthy control (HC) subjects were recruited. MRI data were obtained, and bilateral ChP and brain ventricle volumes were evaluated using segmentation, based on the adaptive multiscale and expectation maximization method.

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Article Synopsis
  • Major depressive disorder (MDD) is a common mental health issue that affects motivation and pleasure, but its specific relationship with the reward system in first-episode, drug-naïve patients hasn't been explored thoroughly.
  • The study involved 89 MDD patients and 82 healthy controls, investigating how the fronto-striato network (FSN) relates to age and depression scores while finding age's effect on FSN only in healthy individuals.
  • Results showed that the FSN is influenced by both age and MDD, indicating a complex interaction, but there was no direct correlation between FSN and severity of depressive symptoms as measured by the Hamilton Rating Scale.
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  • The study investigated resting-state functional connectivity (rsFC) in individuals with anorexia nervosa (AN) using functional MRI data from 114 patients and 135 healthy controls, addressing limitations from previous research due to small sample sizes.
  • Results indicated that AN patients exhibited 12 areas of stronger connectivity primarily in the dorsolateral prefrontal cortex, and 33 areas of weaker connectivity, particularly in regions associated with the cerebellum, temporal lobe, and visual network.
  • The findings suggest that the patterns of rsFC could serve as potential diagnostic markers to differentiate AN patients from healthy individuals, with notable distinctions observed between AN subtypes.
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Rationale And Objectives: Although hyperintensity in the anterior portion of the callosal splenium on FLAIR (aCS-hyperintensity) is a common finding in elderly adults, no previous studies have examined the clinical significance. In this large elderly population study, we aimed to investigate the associations of aCS-hyperintensity with vascular risk factors, cognitive decline, and other MRI measurements.

Materials And Methods: This cross-sectional study included 2110 participants (median age, 69 years; 61.

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Purpose: To evaluate the diagnostic value of T1-weighted 3D fast spin-echo sequence (CUBE) with deep learning-based reconstruction (DLR) for depiction of pituitary adenoma and parasellar regions on contrast-enhanced MRI.

Methods: We evaluated 24 patients with pituitary adenoma or residual tumor using CUBE with and without DLR, 1-mm slice thickness 2D T1WI (1-mm 2D T1WI) with DLR, and 3D spoiled gradient echo sequence (SPGR) as contrast-enhanced MRI. Depiction scores of pituitary adenoma and parasellar regions were assigned by two neuroradiologists, and contrast-to-noise ratio (CNR) was calculated.

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Article Synopsis
  • - A multicenter study aimed to identify brain abnormalities in women with anorexia nervosa (AN) using structural MRI, addressing limitations of previous research related to small sample sizes.
  • - The study included 103 AN patients and 102 healthy controls, analyzing gray matter volume (GMV) and the relationship between brain structure and severity of eating disorder symptoms.
  • - Key findings indicated significant reductions in GMV in various brain regions of AN patients, with some areas showing positive correlations with symptom severity, enhancing the understanding of AN's pathogenesis and potential imaging biomarkers.
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Objectives: Previous studies have shown possible choroid plexus (CP) dysfunction in Alzheimer's disease (AD) and highlighted CP enlargement on magnetic resonance imaging (MRI) as a predictive factor of AD. However, few studies have assessed the relationship between CP volume (CPV) and mild cognitive impairment (MCI). In this large elderly population study, we investigated the changes in CPV in patients with MCI using MRI above 65 years.

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Gastric artery injury resulting from blunt abdominal trauma is rare, with only eight previous cases documented in the published literature. Our report describes a case involving an injury to the right gastric artery with concomitant injuries to the liver and spleen, for which arterial embolization targeting the right gastric artery was performed. The patient, a 66-year-old woman without any remarkable medical history, was involved in a motor vehicle accident.

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Objective: To investigate the effect of electroconvulsive treatment (ECT) on dynamic structural network connectivity in major depressive disorder (MDD), based on the triple-network model.

Methods: Twenty-one first-episode, drug-naïve patients with MDD and 21 age- and sex-matched healthy subjects were recruited. Bilateral electrical stimulation was performed thrice a week for a total of 4-5 weeks in the MDD group.

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Although altered networks inside the hippocampus (hippocampal intra-networks) have been observed in dementia, the evaluation of hippocampal intra-networks using magnetic resonance imaging (MRI) is challenging. We employed conventional structural imaging and incident component analysis (ICA) to investigate the structural covariance of the hippocampal intra-networks. We aimed to assess altered hippocampal intra-networks in patients with mild cognitive impairment (MCI).

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Introduction: Despite the previous inconsistent findings of structural and functional abnormalities of the thalamus in patients with major depressive disorder (MDD), the disruption of the thalamic nuclei in the pathophysiology of this disorder has not yet been adequately studied. Therefore, we investigated the volumetric changes of thalamic subregions and their nuclei in drug-naïve, first-episode MDD patients. We also investigated the association between HAM-D scores, a clinical scale frequently used to evaluate the severity of depression and thalamic nuclei volumes in MDD patients.

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Article Synopsis
  • The study explores the use of a new imaging technique called deep learning-based reconstruction (DLR) to enhance MRI scans for better identification of multiple sclerosis (MS) lesions.
  • Researchers compared the effectiveness of a high-resolution 1 mm-slice MRI (with DLR) to conventional 5 mm-slice MRI in detecting MS lesions in 42 patients.
  • Results showed that the 1 mm T2-weighted MRI with DLR detected significantly more lesions than the standard method, especially in the brain stem, suggesting that this technique could be valuable in clinical practice.
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  • The study investigates how brain volume is affected in elderly individuals with varying levels of dysglycemia, particularly focusing on the prediabetic stage and its potential impact on brain health.
  • It involved 2,144 participants with an average age of 69, categorized into groups based on their HbA1c levels, identifying those with normal glucose metabolism, prediabetes, undiagnosed diabetes, and known diabetes.
  • Results indicated that participants with prediabetes, undiagnosed diabetes, and known diabetes had significantly lower total gray matter volume compared to those with normal glucose metabolism, suggesting that high blood sugar levels can harm brain integrity even before diabetes is officially diagnosed.
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Background And Objectives: Cortical structural changes in major depressive disorder (MDD) are usually studied using a voxel-based morphometry approach to delineate the cortical gray matter volume. Among cortical structures, gyrification patterns are considered a relatively stable indicator. In this study, we investigated differences in gyrification patterns between MDD patients and healthy controls (HCs) and explored the association of gyrification patterns with plasma brain-derived neurotrophic factor (BDNF) levels and depressive symptoms in MDD patients.

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Article Synopsis
  • PADRE imaging effectively enhances the visualization of myelin density, allowing for better differentiation of the superior cerebellar peduncle (SCP) in patients with progressive supranuclear palsy (PSP) compared to those with Parkinson's disease (PD).
  • In a study involving 20 PSP and 31 PD patients, measurements revealed that the SCP was significantly smaller in PSP (1.1 mm) than in PD (2.4 mm), with PADRE achieving high diagnostic sensitivity (93.5%) and specificity (100%).
  • The results demonstrated that PADRE imaging had superior diagnostic performance compared to traditional 3D-T1WI parameters for differentiating between PSP and PD.
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Complex networks inside the hippocampus could provide new insights into hippocampal abnormalities in various psychiatric disorders and dementia. However, evaluating intra-networks in the hippocampus using MRI is challenging. Here, we employed a high spatial resolution of conventional structural imaging and independent component analysis to investigate intra-networks structural covariance in the hippocampus.

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Background: Neurological symptoms and radiographic abnormalities may remain in a small proportion of patients with metronidazole-induced encephalopathy (MIE). Although experimental animal models of MIE have suggested a Wernicke's encephalopathy-like pathology, little is known about the histopathological features of MIE. Here we report the first autopsy case of irreversible MIE.

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  • Visual hallucinations (VH) are common in Lewy body disease (LBD), including conditions like Parkinson's disease and dementia, and the study explored the use of phase difference enhanced imaging (PADRE) to identify structural changes in the optic radiation (OR) of these patients.
  • Two radiologists analyzed the OR in healthy subjects and LBD patients to determine abnormalities, finding significant differences between those with VH and those without; they identified three distinct layers in healthy subjects' OR and defined abnormalities by obscured layers.
  • The findings revealed that 57% of patients with LBD and identified abnormal OR developed VH during follow-up, suggesting that assessing OR abnormalities via PADRE could serve as a valuable marker to differentiate between patients with and
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  • The study explored how grey matter (GM) volume in the brain relates to blood biomarkers, blood pressure, and obesity among 1799 participants during a medical checkup.
  • Researchers used MRI scans to measure GM volume and calculated a GM healthcare quotient (GM-BHQ) to analyze the data.
  • The findings indicated that higher body mass index (BMI), along with certain blood markers, could be linked to decreases in GM volume, although the study could not establish a cause-and-effect relationship.
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The aim of the present study was to investigate associations between hippocampal subfield volumes and plasma levels of brain-derived neurotrophic factor (BDNF) in patients experiencing a first episode of major depression (MD) ( = 30) as compared to healthy controls (HC) ( = 49). Covariate-adjusted linear regression was performed to compare the MD and healthy groups, adjusting for age, sex, and total estimated intracranial volume. We demonstrated that there were no differences in total hippocampal volume between the MD and HC groups.

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Article Synopsis
  • * The study focused on comparing the amygdala's volume and plasma levels of brain-derived neurotrophic factor (BDNF) and cortisol between MDD patients and healthy controls, both with the same genetic s/s serotonin transporter gene variant.
  • * Findings showed no significant differences in amygdala volume or plasma levels of BDNF and cortisol between the two groups, and no correlations were found between amygdala volume and these plasma levels.
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Objective Olfactory dysfunction is an important clinical feature in patients with multiple sclerosis (MS). The incidence and extent of olfactory dysfunction are reportedly higher in secondary progressive (SP) MS than in relapsing and remitting (RR) MS. We investigated the use of olfactory dysfunction for evaluating the disease status of Japanese patients with MS.

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