Publications by authors named "Kajiang Yu"
J Mol Cell Biol
October 2018
Article Synopsis
- The leptin receptor (LepRb) signaling pathway in the hypothalamus regulates food intake and energy use, and defects can lead to leptin resistance and obesity.
- Research on Lztfl1, a gene linked to Bardet-Biedl syndrome, reveals that global deletion of this gene in mice leads to obesity and hyperphagia, primarily due to its absence in the brain rather than fat tissue.
- Lztfl1 deficiency disrupts leptin signaling by preventing the phosphorylation of Stat3 in the hypothalamus, suggesting that Lztfl1 is critical for normal leptin function and may also influence ciliary structure through interactions with specific proteins.
