Xylazine-Induced Necrotic Skin Ulcers in a Fentanyl-Injecting Individual in South Florida, United States: A Case Report.

Xylazine, commonly referred to as "Tranq," is an alpha-2-adrenergic receptor agonist that is FDA-approved only as a sedative and tranquilizer for veterinary use. However, its use as an adulterant in various illicit drugs, including fentanyl, has been on the rise, leading to its street name, "Tranq-Dope." Intravenous injection use of xylazine produces distinctive skin ulceration with accompanying necrosis, which can be considered virtually pathognomonic.

Degradation of Plastic Beads Containing Low Density Polyethylene (LDPE) by Sequential Photolysis, Hydrolysis and Bacterial Isolates.

Plastic is an important part of today's human daily lifestyle, and it is classified as a "global pollutant" due to its durability. The natural degradation of plastic is extremely slow and will take a hundred years or more. The ultimate destinations of plastics as well as their effects on the ecosystem vary with the type of plastic and the rate of their degradation.

Automated molecular detection of West Nile Virus in mosquito pools using the Panther Fusion system.

West Nile Virus (WNV) is an arthropod-borne virus that is spread through mosquito vectors. WNV emerged in the US in 1999 and has since become endemic in the US, causing the most domestically acquired arboviral disease in the country. Mosquito surveillance for WNV is useful to monitor arboviral disease burden over time and across different locations.

Presence of kratom in opioid overdose deaths: findings from coroner postmortem toxicological report.

Background: Kratom () use in the United States is becoming increasingly popular and its legal status varies widely from state to state. Multiple reports of adverse events associated with kratom use have ranged from liver injury, seizures, psychiatric disturbance, and rarely death.

Methods: This study investigated coroner autopsy reports from Kern County in California for the year 2020 which included qualitative data on substances from blood toxicological reports.

Impact of anthropogenic land uses on soil microbiological activity in a peri-urban landscape.

Land use and land cover patterns impact soil properties and negatively affect soil microbial community and related processes. However, the information regarding the influence of urban land use on soil microbial composition and functioning is limited. Here, we investigated the impact of urban land use patterns on soil microbiological parameters by comparing five contrasting anthropogenic land use classes, i.

Roundtable on Young Adults with IBD: A multi-stakeholder perspective and patient-driven analysis of the current transitional challenges and gaps in research.

The "Roundtable on Young Adults with IBD" is a year-long learning community consisting of monthly discussions between providers, patients, and healthcare partners. The group aims to enhance outcomes for the young adult IBD patient population. The first discussion centered on the difficulties that IBD patients face during the transition from pediatric to adult care and how care can be improved for young adult patients during this phase.

Assessing the efficacy of probiotics in augmenting bovine reproductive health: an integrated , , and study.

The aim of this study was to isolate and characterize bovine-vaginal probiotics genotypically and phenotypically using and evaluate their performance in buffaloes with endometritis. For the isolation and characterization, vaginal swabs were collected from 34 cows and 17 buffaloes, and 709 primary bacterial isolates with probiotic activity were obtained using MRS agar media. Two isolates KUGBRC (LPKUGBRC) and GBRCKU (PPGBRCKU) demonstrated optimum probiotic activities as compared to GG including, acid production, secretion of fatty acids and exopolysaccharide, cell surface hydrophobicity, self-aggregating and co-aggregating capacity with pathogens, anti-microbial activity and bacteriocin-like compounds against pathogens and in cell-free supernatant and absence of hemolytic activity.

Enhancing an AI-Empowered Periodontal CDSS and Comparing with Traditional Perio-risk Assessment Tools.

Periodontal disease (PD) is one of the most prevalent dental diseases. Fortunately, it can be prevented if identified early, especially for high-risk patients. Dental electronic health records (EHRs) could help develop a data-driven personalized prediction model using advanced machine learning development of clinical decision support system (CDSS) as in our Phase I, II AMIA-AI showcase.

Allergic contact dermatitis from propylene glycol: A case series from Australia.

Background: Propylene glycol (PG) is used in a variety of cosmetics, food and pharmaceuticals. PG is a known sensitizer but also irritating when patch tested (PT).

Objectives: The aims were to investigate the frequency of contact sensitization to PG and to identify cases of allergic contact dermatitis (ACD).

Shy, happy, calm, and controlled: Temperament correlates of socioemotional adjustment in toddlerhood.

Understanding heterogeneity in shy or inhibited children's risk for poor socioemotional adjustment can inform intervention targets. The present study considered temperament traits associated with approach and regulation that may alter trajectories away from internalizing behaviors and poor socioemotional competence among shy toddlers. Fifty-five 22-24-month-old children (22 boys) preselected for parent-reported shyness were observed during laboratory tasks designed to measure shyness, activity level, positive affect, and inhibitory control between January 2016 and January 2018.

Diagnostic Accuracy of Elastography and Liver Disease: A Meta-Analysis.

Background: Ultrasound-based transient elastography (TE) is a non-invasive alternative to liver biopsy for the staging of hepatic fibrosis due to various chronic liver diseases. This meta-analysis aims to assess the diagnostic accuracy of TE for detecting liver cirrhosis (F4) and severe fibrosis (F3) in patients with chronic liver diseases, in comparison to the gold standard liver biopsy.

Methods: A systematic search was performed using PubMed search engine following Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines from inception to May 2021.

Heavy metal accumulation in leaves of selected plant species in urban areas of Delhi.

Heavy metals beyond their permissible limits are major contaminants and causes of concern due to their persistent nature and health hazards. Several studies validated the utilization of plants as biomonitors and bioaccumulators for heavy metal pollution. Therefore, this study was conducted to examine the proficiency for heavy metal monitoring and mitigation by commonly found plant species in urban areas of Delhi.

Urban dust pollution tolerance indices of selected plant species for development of urban greenery in Delhi.

The rise in urbanization has led to an increase in dust pollution which is hazardous to the health of living beings. The role of roadside plant species in intercepting particulate matter and improving air quality is well reported. Hence, this study was carried out to determine the ability of various plant species to intercept atmospheric dust and withstand the abiotic stress triggered by dust deposition.

Presence of entry receptors and viral markers suggest a low level of placental replication of hepatitis B virus in a proportion of pregnant women infected with chronic hepatitis B.

The transplacental route of vertical transmission of Hepatitis B Virus (HBV) has been known for over a decade. Here we present evidence which suggest HBV can replicate in placenta. Forty-one HBsAg positive and 10 control pregnant women were enrolled in the study after obtaining informed consent.

Anti-cholinergic drug burden in patients with dementia increases after hospital admission: a multicentre cross-sectional study.

Background: Anticholinergic medications are drugs that block cholinergic transmission, either as their primary therapeutic action or as a secondary effect. Patients with dementia may be particularly sensitive to the central effects of anticholinergic drugs. Anticholinergics also antagonise the effects of the main dementia treatment, cholinesterase inhibitors.

South Asians Active Together (SAATH): Protocol for a multilevel physical activity intervention trial for South Asian American mother and daughter dyads.

South Asian (SA), including Asian Indian and Pakistani Americans, have a high burden of cardiometabolic risk factors and low levels of physical activity (PA). Increasing PA in the U.S.

In-Depth Analysis of an Obligate Anaerobe Isolated from Uterus of .

Chronic non-specific contamination of the reproductive tract in animals is a major issue during early postpartum, natural coitus, or artificial insemination. Uterine infection is one of the major concerns reducing fertility, production loss, and early culling of the animals. Therefore, the aim of this study was to identify any novel bacterium if present in the uterine environment of causing infections.