Publications by authors named "Kajal Pande"
Laccases are copper-containing enzymes belonging to the family of multicopper oxidases (MCOs). All MCOs use molecular oxygen to oxidize a wide range of organic compounds by radical catalysis. One of the key fundamental properties of laccases is having high or low redox potentials depending on the active site organization.
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- Researchers are investigating how SARS-CoV-2 infects lung cells by studying its protein interactions, particularly between the viral spike protein's receptor-binding domain (RBD) and the human ACE2 receptor.
- The study used computational methods like binding affinity calculations and molecular dynamics simulations to find that SARS-CoV-2 binds more strongly to ACE2 than its predecessor, SARS-CoV, and identified important water molecules at the interaction site that stabilize this binding.
- Experimental validation confirmed these findings, and the research suggests that understanding these molecular interactions could lead to new treatments and vaccines against the virus.