Effects of lorazepam on saccadic eye movements - evidence from prosaccade and free viewing tasks.

Rationale: Peak velocities of saccadic eye movements are reduced after benzodiazepine administration. Even though this is an established effect, past research has only examined it in horizontal prosaccade tasks.

Objectives: The spectrum of saccadic eye movements, however, is much larger.

GABAergic Involvement in Selective Attention.

Animals need to cope with abundant sensory information, and one strategy is to selectively direct attention to only the most relevant part of the environment. Although the cortical networks of selective attention have been studied extensively, its underlying neurotransmitter systems, especially the role of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), remain less well understood. Increased GABAA receptor activity because of administration of benzodiazepines such as lorazepam is known to slow reactions in cognitive tasks.

Latent state-trait and latent growth curve modeling of inhibitory control.

The reliability of inhibitory control task performance as well as the existence of an underlying unitary inhibitory construct have been questioned. The present study is the first to use a trait and state decomposition approach to formally quantify the reliability of inhibitory control and to examine its hierarchical structure. = 150 participants carried out antisaccade, Eriksen flanker, go/nogo, Simon, stop-signal, and Stroop tasks on three occasions.

Beyond sleep: A multidimensional model of chronotype.

Chronotype can be defined as an expression or proxy for circadian rhythms of varied mechanisms, for example in body temperature, cortisol secretion, cognitive functions, eating and sleeping patterns. It is influenced by a range of internal (e.g.

The role of the SLC6A3 3' UTR VNTR in nicotine effects on cognitive, affective, and motor function.

Rationale: Nicotine has been widely studied for its pro-dopaminergic effects. However, at the behavioural level, past investigations have yielded heterogeneous results concerning effects on cognitive, affective, and motor outcomes, possibly linked to individual differences at the level of genetics. A candidate polymorphism is the 40-base-pair variable number of tandem repeats polymorphism (rs28363170) in the SLC6A3 gene coding for the dopamine transporter (DAT).

GABAergic modulation of performance in response inhibition and interference control tasks.

Background: Inhibitory control is a crucial executive function with high relevance to mental and physical well-being. However, there are still unanswered questions regarding its neural mechanisms, including the role of the major inhibitory neurotransmitter, γ-aminobutyric acid (GABA).

Aims: This study examined the effects of lorazepam (0.

Physical and Cultural Inheritance Enhance Agency, but What are the Origins of this Concern to Establish a Legacy? A Nationally-Representative Twin Study of Erikson's Concept of Generativity.

Generativity-showing concern to establish and guide future generations-has been argued to be a biological adaptation central to cumulative culture and survival, but also, in turn, to be a cultural adaptation dependent on norms. From the perspective of human agency, concern for the future has played a key role in raising agency for generations that follow by creating infrastructure and cultural inheritance. Here, in a population-representative sample of 756 twin-pairs, we present the first test of the genetic and environmental structure of generativity using the Loyola Generativity Scale (short).

Association of Schizotypy With Dimensions of Cognitive Control: A Meta-Analysis.

Schizotypy is defined as a time-stable multidimensional personality trait consisting of positive, negative, and disorganized facets. Schizotypy is considered as a model system of psychosis, as there is considerable overlap between the 2 constructs. High schizotypy is associated with subtle but fairly widespread cognitive alterations, which include poorer performance in tasks measuring cognitive control.