Publications by authors named "Kaj Korhonen"
Background: An active use of inhaled corticosteroids for asthma has been associated with less asthma exacerbations and hospital admissions in children aged more than 2 years. The present study aimed to investigate hospital admission rates in young children from two populations in relation to the age-specific use of maintenance medication for asthma.
Methods: Annual data on children aged less than 24 months treated for asthma, including data on the use of maintenance medication based on the purchases of prescribed medications, and annual numbers of admissions to hospital and proportions of readmissions, were collected from 1995 to 1999 in two provinces of Finland.
Background: Characteristics related to decreased lung function and increased bronchial responsiveness after early childhood wheezing requiring hospitalization are not fully established.
Methods: Seventy-nine children with wheezing requiring hospitalization at age <2 years were prospectively followed up and re-investigated at age 5.6-8.
Background: Recent studies have stressed the influence of other viruses than respiratory syncytial virus (RSV) in the development of asthma in later childhood after bronchiolitis in infancy. However, the virus-specific prognosis until adulthood has remained obscure, due to lack of sufficiently long follow-up studies. The aim of the present study was to evaluate adult respiratory morbidity after bronchiolitis in infancy, focused on cases not caused by RSV.
View Article and Find Full Text PDFBackground: The aim of the present study was to evaluate the prevalence of sensitization to molds and to house dust mites (HDM) in pre-school children with newly-diagnosed asthma.
Methods: From 1996 to 2000, 122 children 1 to 6 years of age with fresh asthma treated in the Kuopio University Hospital, Kuopio, Finland, were recruited in the study; 94% attended. Skin prick tests were performed to common inhalant allergens and to 10 molds.
In the present cohort, 85% of infants hospitalized for wheezing outgrew their symptoms until puberty, but 30-40% had asthma, depending on criteria, again in young adulthood. The aim of this study was to determine early predictors for adulthood asthma, bronchial reactivity, and lung function abnormalities in infants hospitalized for bronchiolitis. Fifty-two children hospitalized for bronchiolitis at < 2 years of age were restudied at the median age of 19 years.
View Article and Find Full Text PDFArticle Synopsis
- Some doctors think that babies and young kids who wheeze and respond to certain medicines might have asthma or could get it later.
- A study was done with 100 wheezing infants to see how they reacted to two types of inhalers: albuterol and racemic epinephrine.
- The results showed that, while oxygen levels improved more with albuterol for kids who had asthma as they grew, both groups didn’t show major differences in how they responded to the medicines when they were infants.
Background: In order to affect the natural course of childhood wheezing and asthma, anti-inflammatory therapy is often prescribed for young wheezing children, but there is lack of long-term follow-up data.
Methods: Eighty-two of the original 100 children, hospitalized for wheezing under the age of 2 years in 1992-1993, were re-examined at school age in 1999. The children had participated in an open, randomized, parallel-group trial including a 4-month intervention with inhaled sodium cromoglycate (SCG) or budesonide (BUD).
Article Synopsis
- The study looked at children who had bronchiolitis or pneumonia when they were babies to see if they developed asthma when they got older.
- Researchers checked 127 kids and found that about 14% to 23% of those with bronchiolitis and 12% to 15% of those with pneumonia had asthma as teenagers.
- They found that factors like wheezing, skin allergies, and high eosinophils in blood were linked to having asthma later, but the study couldn't prove that early RSV infections specifically caused asthma in teens.
Article Synopsis
- Researchers studied 81 kids who had wheezing when they were younger than 2 years to see if it affected their asthma later on.
- When the kids turned about 12 years old, they checked for asthma symptoms and found that 40% of them had asthma and were usually allergic to something.
- They learned that early signs of asthma included skin conditions like atopic dermatitis and allergies, and that getting some viruses when they were babies, especially rhinovirus, made asthma more likely to happen later.
Objective: To determine the outcome until adulthood after wheezing in infancy, compared with pneumonia in infancy and with controls.
Design: An 18- to-20-year prospective cohort study.
Setting: Pediatric department at a university hospital, providing primary hospital care for a defined population.
Article Synopsis
- The study looked at if measuring certain IgE antibodies in wheezing babies can help predict if they will have asthma later when they grow up.
- It followed 82 babies who had wheezing problems and checked them again when they reached school age.
- Results showed that high levels of IgE for foods like wheat and egg white, as well as some inhalant allergens, were linked to later asthma, helping doctors identify asthma risk early on.
Rhinovirus-induced wheezing in infancy--the first sign of childhood asthma?
J Allergy Clin Immunol
January 2003
Article Synopsis
- Some common viruses, like rhinoviruses, enteroviruses, and coronaviruses, are linked to wheezing in babies, but not much research has been done on them.
- The study looked at 82 babies who had wheezing problems and found that rhinoviruses were the most common virus present.
- The results suggest that rhinoviruses could be important in causing wheezing and might lead to asthma later in childhood, especially for babies with skin allergies (atopy).
Article Synopsis
- A study looked at children who wheezed when they were younger than 2 to see if they would develop asthma by age 7.
- Out of 82 kids, 33 of them (about 40%) had asthma when they were re-tested later.
- Key factors that increased the chances of getting asthma included having high levels of certain blood cells, skin allergies, and having wheezed a lot as babies.