RON receptor tyrosine kinase as a critical determinant in promoting tumorigenic behaviors of bladder cancer cells through regulating MMP12 and HIF-2α pathways.

The RON receptor tyrosine kinase is critical in the pathogenesis of various cancer types, however, its role in bladder cancer invasive growth is still largely unknown. Here, we found that over 90% of bladder cancer samples exhibit elevated levels of RON expression, with significantly higher expression levels observed in invasive bladder cancer compared to non-invasive bladder cancer. In vitro, RON activation resulted in increased bladder cancer cell migration and invasiveness.

Sublethal effects of nitenpyram on the development of silkworm.

The utilization of nitenpyram for aphid and whitefly control may induce environmental contamination and negative repercussions on non-target organisms. Formerly, we found that nitenpyram would pollute the peripheral and sub-peripheral areas of the adjacent mulberry orchard. Under acute toxicity conditions, nitenpyram induced oxidative damage in silkworms, affected biological metabolism, synthesis, immunity, and signal transduction.

Comparison of perfluoroalkyl substance adsorption performance by inorganic and organic silicon modified activated carbon.

Owing to the persistence and increasingly stringent regulations of perfluoroalkyl substances (PFAS), it is necessary to improve their adsorption capacities using activated carbon (AC). However, their adsorption capacities are suppressed by dissolved organic matter (DOM). In this study, two ACs modified with organic silicon (C-OS) and inorganic silicon (C-IS) were synthesized and used for the adsorption of PFAS in raw water (RW).

The down-regulation of GADD45B leads to a conversion of cellular oxidative phosphorylation to glycolysis and promotes the progression of bladder cancer.

Background: The predominant feature of cancer cells during the process of carcinogenesis is the inclination towards glycolytic metabolism rather than mitochondrial oxidative phosphorylation. Nevertheless, there is a scarcity of research investigating the correlation between bladder cancer and mitochondrial energy metabolism.

Methods: A qPCR array comprising 90 genes associated with mitochondrial oxidative phosphorylation was employed to discern metabolic disparities between three sets of bladder cancer tissue and adjacent normal tissue.

Transformation of Al Species on Carbon Surfaces: Effects of Al Species and Carbon Surface Oxygen Groups.

Control of residual Al is critical, owing to its high tendency to accumulate in drinking water distribution systems and its potential risks to human health. Herein, the effects of surface properties of activated carbon (AC) on intercepting different Al species (including monomeric Al and polymeric Al species-Al) are evaluated. The results showed that Al in the form of monomers was considerably adsorbed by AC; whereas Al in the form of polymeric Al was held to a much lower degree by AC, and the effluent Al concentration was even higher than that without AC.

Validating the role of PTGIS gene in colorectal cancer by bioinformatics analysis and in vitro experiments.

Prostaglandin I2 synthase (PTGIS) is a member of the cytochrome P450 family. Studies have revealed that differential expression of the PTGIS gene is closely related to the pathological and physiological processes of many diseases, including breast cancer, oral squamous cell carcinoma, and head and neck cancer. However, the mechanism of action of the PTGIS gene in colorectal cancer is not fully understood.

Track Fastener Defect Detection Model Based on Improved YOLOv5s.

Defect detection of track fasteners is a prerequisite for safe and reliable railroad operation. The traditional manual visual inspection method has been unable to meet the growing demand for railroad network inspection in China. To achieve the need for accurate, fast, and intelligent detection of rail fasteners, this paper proposes a rail fastener defect detection model based on improved YOLOv5s.

Sublethal Effects of Neonicotinoid Insecticides on the Development, Body Weight and Economic Characteristics of Silkworm.

Silkworm (L.) (Lepidoptera: Bombycidae) is a critical insect for silk producers, but the inappropriate application of insecticides negatively affects the physiology and behavior of silkworms. This study found that the effects of neonicotinoid insecticides applied using two spraying methods on the growth and development of silkworms were different: the median lethal concentration (LC) values of two pesticides applied using the leaf-dipping method were 0.

Suppression of performance of activated carbon filter due to residual aluminum accumulation.

Extending the lifetime of granular activated carbon (GAC) filters with no significant loss in their effectiveness is a considerable challenge for drinking water supply utilities. However, the effects of residual Al from coagulants on GAC performance are rarely considered. Herein, in-service GAC samples obtained from full-scale water treatment plants were investigated to evaluate the amount of accumulated Al.

Inhibition of Wnt7b reduces the proliferation, invasion, and migration of colorectal cancer cells.

Objective: Colorectal cancer is one of the most common gastrointestinal tumors. The role of Wnt7b as a ligand of the Wnt signaling pathway in colorectal cancer remains to be studied. Through bioinformatics online analysis, we found that Wnt7b is abnormally highly expressed in a variety of gastrointestinal tumors.

Toxicity of nitenpyram to silkworm (Bombyx mori L.) and its potential mechanisms.

Silkworm (Bombyx mori L.), as an economic insect, occupies a certain position in the development of China's economy. The neonicotinoid insecticide nitenpyram is commonly used in farmland to control planthoppers and aphids.

Control efficiency of hexaconazole-lentinan against wheat sharp eyespot and wheat crown rot and the associated effects on rhizosphere soil fungal community.

The use of polysaccharides to induce the systemic immune response of plants for disease resistance has become an effective plant protection measure. Sharp eyespot wheat and crown rot wheat are serious diseases of wheat. In this study, the control effects of hexaconazole and lentinan (LNT) seed dressing of the two wheat diseases were evaluated by field experiments, and the effects of the seed dressing on plant growth, soil enzyme activity, and community diversity in the wheat rhizosphere were discussed.

Biocontrol activity and action mechanism of strain SDTB038 against Fusarium crown and root rot of tomato.

Fusarium crown and root rot of tomato is a soilborne diseases that has brought serious harm and economic losses to tomato production in facilities in recent years. The disease has been reported in more than 30 countries worldwide, but there are few reports on its biological control. A strain SDTB038 with biocontrol effects was isolated and identified in a previous study and is considered one of the most important PGPRs.

The expression and significance of p4E-BP1/4E-BP1 in prostate cancer.

Background: Although the phosphorylation of 4E-BP1 that has been detected in high-grade prostate cancer has been reported in previous studies, overexpression of p4E-BP1 and 4EBP1 and their clinical significance in prostate cancer still remain unknown.

Methods: One hundred six samples of prostate tissues were collected and analyzed by immunohistochemistry with p4E-BP1 or 4E-BP1 specific antibodies. Everolimus was used to block the phosphorylation of p4E-BP1, and then flow cytometry, clone formation, transwell, and wound healing assays were performed to detect the survival and invasive ability of the prostate cancer cells.

Four MicroRNAs, miR-13b-3p, miR-278-5p, miR-10483-5p, and miR-10485-5p, Mediate Insecticide Tolerance in .

is the world's major agricultural pest and has the distinctive features of high fecundity, strong migratory capacity, and high resistance to most insecticides. At present, the control of in China relies mainly on the spraying of chemical insecticides. MicroRNAs (miRNAs) are a class of small, single-stranded, non-coding RNAs and play crucial regulatory roles in various physiological processes, including the insecticide resistance in insects.

Medical evaluation and pharmacotherapeutical strategies in management of urolithiasis.

Treatment of urolithiasis depends on several important factors which include stone location, size, composition, and patient symptoms. Although significant advancements have been made in the surgical management of urolithiasis in the last decade, pharmacotherapy which can prevent the formation of new stones and decrease the recurrence of urolithiasis has not experienced the same level of success. Currently, urolithiasis is regarded as a complicated syndrome that is determined by numerous factors, and any treatment plan for urolithiasis should be individualized while considering any potential damage arising from stone-forming factors.

Emodin Induced Necroptosis and Inhibited Glycolysis in the Renal Cancer Cells by Enhancing ROS.

Renal cell carcinoma (RCC) is a tumor with unpredictable presentation and poor clinical outcome. RCC is always resistant to chemotherapy and radiation, and weakly sensitive to immunotherapeutic agents. Therefore, novel agents and approaches are urgently needed for the treatment of RCC.

Antagonistic Activity of SDTB038 against in Potato.

Potato late blight is a severe and highly epidemic disease caused by that can affect all parts of the plant. This study mainly screened antagonistic strains for good control of potato late blight and identified strain SDTB038 as according to its morphological and chemical properties and the 16S rRNA, , and gene sequences. This antagonistic strain achieved good control of potato late blight in greenhouses and fields and promoted potato plant growth.

Efficacy and safety of docetaxel and prednisolone chemotherapy in very elderly men with metastatic castration-resistant prostate cancer (mCRPC) in real world: a single institute experience.

Background: Prostate cancer is the most common type of malignancy in elderly men. Although elderly patients are commonly encountered in clinical practice, few studies have focused on the value of chemotherapy in elderly patients. In this study, we reviewed the use of docetaxel with prednisolone in elderly men (aged ≥80 years) with metastatic castration-resistant prostate cancer (mCRPC) at Ningbo First Hospital with a focus on efficacy and toxicity.

Up-Regulation of RIP3 Alleviates Prostate Cancer Progression by Activation of RIP3/MLKL Signaling Pathway and Induction of Necroptosis.

Background: The receptor-interacting protein kinase 3 (RIP3/RIPK3) was recently found to be a critical regulator of programmed necrosis/necroptosis. However, the biological role and clinical significance of RIP3 in prostate cancer remain obscure.

Methods: Western blotting and QRT-PCR were performed to detect the level of RIP3 in prostate cancer cells.

Progress in applications of F-fluciclovine in diagnosis of prostate cancer.

Prostate cancer is the most common malignancy tumor among men in developed countries. The incidence rate in recent years is also increasing in China. With the development of technology, the application of PET/CT examination has been augmented in the diagnosis of prostate cancer.

Advantages of retrograde flexible ureteroscopy in determining the etiology of painless hematuria originating from the upper urinary tract.

The present study investigated the use of retrograde flexible ureteroscopy (RFU) in the discrimination of the etiology of hematuria that originates from the upper urinary tract (UUT). The present study collected retrospective data for patients who presented with hematuria and cystoscopy-detected bleeding from the UUT between June 2006 and August 2018 in Ningbo First Hospital. All patients accepted RFU to determine the etiology of hematuria.

Use of Ganoderma Lucidum polysaccharide to control cotton fusarium wilt, and the mechanism involved.

Induced resistance is an effective measure for controlling plant diseases by utilizing the natural defense of the host and meets the strategic needs of pesticide application and safety for agricultural products worldwide. Ganoderma lucidum polysaccharide (GLP), which is the main active molecule of G. lucidum, has been widely used in functional food and clinical medicine.

Comparison of levofloxacin-based prophylaxis regimens for transrectal prostate biopsy: a prospective randomized single-center study.

To develop an optimal prophylactic regimen among Chinese patients who accept transrectal prostate biopsy. We enrolled 420 patients who accepted transrectal prostate biopsy. They were randomly classified into three groups (n = 140 for each): Group A received a single 500-mg tablet of levofloxacin without enema; group B received a single 500-mg tablet of levofloxacin plus enema; group C received 3-day levofloxacin orally plus enema.

Prediction and mitigation of train-induced vibrations of large-scale building constructed on subway tunnel.

Among all the recent improvements in the railway industry, ground vibration remains an important showstopper in metropolitan cities. In some particular cases, significant levels of vibration are felt by residents. The role of engineers is to propose mitigation solutions and to ensure that they are efficient in the long-term.