Bioinformatics identification based on causal association inference using multi-omics reveals the underlying mechanism of Gui-Zhi-Shao-Yao-Zhi-Mu decoction in modulating rheumatoid arthritis.

Object: Rheumatoid arthritis (RA) is a prevalent and currently incurable autoimmune disease. Existing conventional medical treatments are limited in their efficacy, prolonged disease may lead to bone destruction, joint deformity, and loss of related functions, which places a huge burden on RA patients and their families. For millennia, the use of traditional Chinese medicine (TCM), exemplified by the Gui-Zhi-Shao-Yao-Zhi-Mu decoction (GZSYZM), has been demonstrated to offer distinct therapeutic advantages in the management of RA.

Old wine in new bottles: Kaempferol is a promising agent for treating the trilogy of liver diseases.

As a source of various compounds, natural products have long been important and valuable for drug development. Kaempferol (KP) is the most common flavonol with bioactive activity and has been extracted from many edible plants and traditional Chinese medicines. It has a wide range of pharmacological effects on inflammation, oxidation, and tumour and virus regulation.

Preclinical evidence of Yinchenhao decoction on cholestasis: A systematic review and meta-analysis of animal studies.

Cholestasis is an important cause of liver fibrosis and cirrhosis. Yinchenhao decoction has been used as a well-known traditional Chinese medicine used in the treatment of cholestasis for over 2,000 years. The purpose of this systematic review is to evaluate the preclinical evidence of Yinchenhao decoction on cholestasis models.

Purification, characterization, antioxidant, and antitumor activity of polysaccharides isolated from silkworm cordyceps.

Two new water-soluble polysaccharide fractions (SCP II-1 and SCP II-2) were obtained from silkworm cordycepsusing DEAE Sepharose FF and Superose 6 columns chromatography. The characterization of their basic structure was studied by high performance liquid chromatography, high performance ion chromatography, infrared spectroscopy and atomic force microscope (AFM). The results showed that the molecular weight of SCP II-1 and SCP II-2 were 35.

Chiral Mn (Salen) Immobilized on Organic Polymer/Inorganic Zirconium Hydrogen Phosphate Functionalized with 3-Aminopropyltrimethoxysilane as an Efficient and Recyclable Catalyst for Enantioselective Epoxidation of Styrene.

Organic polymers/inorganic zirconium hydrogen phosphate (ZSPP, ZPS-IPPA, and ZPS-PVPA) functionalized with 3-aminopropyltrimethoxysilane were prepared and used to support chiral Mn (salen) complexes (Jacobsen's catalyst). Different characterization methods demonstrated that the chiral Mn (salen) complexes was successfully supported on the surface of the carrier (ZSPP, ZPS-IPPA, or ZPS-PVPA) through a 3-aminopropyltrimethoxysilane group spacer. The supported catalysts effectively catalyzed epoxidation of styrene with -chloroperbenzoic acid (-CPBA) as an oxidant in the presence of -methylmorpholine -oxide (NMO) as an axial base.

Chiral Mn (Salen) Covalently Bonded on Modified ZPS-PVPA and ZPS-IPPA as Efficient Catalysts for Enantioselective Epoxidation of Unfunctionalized Olefins.

hiral Mn (salen) complex supported on modified ZPS-PVPA (zirconium poly(styrene-phenylvinylphosphonate)) and ZPS-IPPA (zirconium poly(styrene-isopropenyl phosphonate)) were prepared using ⁻CH₂Cl as a reactive surface modifier by a covalent grafting method. The supported catalysts showed higher chiral induction (ee: 72%⁻83%) compared with the corresponding homogeneous catalyst (ee: 54%) for asymmetric epoxidation of -methylstrene in the presence of 4-phenylpyridine -oxide (PPNO) as axial base using NaClO as an oxidant. ZPS-PVPA-based catalyst 1, with a larger pore diameter and surface area, was found to be more active than ZPS-IPPA-based catalyst 2.

[Applications of real-time monitoring techniques in chemical synthetic ingredients].

Real-time monitoring technique for process parameters and/or insight variables of chemical synthetic ingredients is a novel chemical process analysis method, which can real time monitor the chemical synthetic ingredients, reveal the mechanism of chemical reaction occurring, reaction courses and kinetic characteristics, and monitor, control and adjust chemical reaction to determine the endpoint of reaction and enhance selectivity of reaction, quality and yields of product. Many real-time monitoring techniques were achieved to satisfy the demands in several chemical synthetic reactions. The structure and principles of current real-time monitoring techniques was stated, and a review was summarized on its applications in chemical synthetic ingredients.