Hybrid biological macromolecules spider-silk fibroin optical patches for efficient wound healing.

Efforts toward developing wound dressings that effectively monitor healing have become at the forefront of the field of wound healing. However, monofunctionality, biotoxicity, and passive therapy constrain wound patches. Herein, a hypoallergenic wound patch integrating moisture monitoring, motion sensing and electrical stimulation for wound healing is presented.

New light-illuminated silk road: emerging silk fibroin-based optical biomedical sensors.

Biomedical silk protein optics has become the subject of intensive research aimed at solving the challenges associated with traditional medical devices in terms of biocompatibility and performance balance. With its significant potential for biomedical applications in the field of drug storage and wound monitoring, it is dedicated to reducing the perturbation of neighbouring tissues. The transparency and biocompatibility of silk proteins make them ideal materials in the field of optical device fabrication, effectively overcoming the challenges posed by conventional materials.

Prevalence and Preferred Niche of Small Eukaryotes with Mixotrophic Potentials in the Global Ocean.

Unicellular eukaryotes that are capable of phago-mixotrophy in the ocean compete for inorganic nutrients and light with autotrophs, and for bacterial prey with heterotrophs. In this study, we ask what the overall prevalence of eukaryotic mixotrophs in the vast open ocean is, and how the availability of inorganic nutrients, light, and prey affects their relative success. We utilized the Oceans eukaryotic 18S rRNA gene and environmental context variables dataset to conduct a large-scale field analysis.

The predictive values of monocyte-lymphocyte ratio in postoperative acute kidney injury and prognosis of patients with Stanford type A aortic dissection.

Objectives: Postoperative acute kidney injury (pAKI) is a serious complication of Stanford type A aortic dissection (TAAD) surgery, which is significantly associated with the inflammatory response. This study aimed to explore the relationship between blood count-derived inflammatory markers (BCDIMs) and pAKI and to construct a predictive model for pAKI.

Methods: Patients who underwent TAAD surgery were obtained from our center and the Medical Information Mart for Intensive Care (MIMIC)-IV database.

Bioinspired 3D-Printed MXene and Spidroin-Based Near-Infrared Light-Responsive Microneedle Scaffolds for Efficient Wound Management.

Biomedical dressings have been comprehensively explored for wound healing; however, the complicated manufacturing process and mono-function of the dressing remain critical challenges for further applications. Here, a versatile extrusion three-dimensional (3D) printing strategy to prepare MXene and spidroin-incorporated microneedle scaffolds with photothermal responsive and self-healing properties for promoting wound healing is proposed. Inspired by the cactus, the microneedle scaffold is composed of a top porous scaffold, and microneedles whose inverse opal (IO) photonic crystal (PC) structure and the ample space between the scaffold gaps endow the microneedle scaffold with high drug-carrying capacity.