Publications by authors named "Kaiyan Shu"
[Huangqi Glycoprotein improves myocardial injury in rats with adjuvant arthritis by interfering with lncRNA GAS5/miR-21/TLR4 signaling axis to inhibit pyroptosis].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
October 2024
Article Synopsis
- - The study aimed to evaluate the protective effects of Huangqi glycoprotein (HQGP) on heart injury in rats suffering from adjuvant arthritis, focusing on the lncRNA GAS5/miR-21/TLR4 signaling pathway.
- - Researchers divided SD rats into four groups and administered treatments after establishing the arthritis model, assessing symptoms, myocardial pathology, and various biochemical markers over four weeks.
- - Results showed that rats in the model group experienced severe inflammation and structural damage to heart tissues, while HQGP treatment appeared to improve these myocardial injury indicators significantly.
Purpose: This study probed the mechanism of action of Xinfeng Capsule (XFC) in myocardial injury in rats with adjuvant arthritis (AA) via the growth arrest-specific transcript 5 (GAS5)/microRNA-21 (miR-21)/Toll-like receptor 4 (TLR4) axis.
Methods: Rats were injected with Freund's complete adjuvant to establish a rat model of AA. Then, some modeled rats were given normal saline or drugs only, and some modeled rats were injected with adeno-associated viruses or necrosulfonamide (NSA; a pyroptosis inhibitor) before drug administration.