Publications by authors named "Kaixing Min"
Article Synopsis
- The study investigates the relationship between specific genetic markers (SNPs) associated with adolescent idiopathic scoliosis (AIS) progression and the effectiveness of brace treatment.
- In a cohort of 259 female AIS patients, it was found that allele C of SNP rs10738445 was significantly linked to an increased risk of bracing failure, with 30.5% of patients experiencing significant curve progression.
- The other four SNPs analyzed (rs12946942, rs1978060, rs1017861, and rs35333564) did not show a significant impact on brace outcomes, indicating the need for further research to enhance prediction models for treatment effectiveness.
Study Design: A genetic case-control study.
Objective: To replicate recently reported genetic loci associated with adolescent idiopathic scoliosis (AIS) in the Chinese Han population, and to determine the relationship between gene expression and the clinical features of the patients.
Summary Of Background Data: A recent study conducted in the Japanese population identified several novel susceptible loci, which might provide new insights into the etiology of AIS.
Background: X-linked early-onset osteoporosis, caused by mutations in plastin3 (PLS3), is an extremely rare disease characterized by low bone mineral density (BMD) and recurrent osteoporotic fractures. There is limited information on genetic and phenotypic spectrum, as well as genotype-phenotype correlations of the disease. Moreover, whether decreased PLS3 levels were also involved in osteoporosis among subjects without PLS3 pathogenic mutations remains unknown.
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