Ethionine-induced S-adenosylmethionine deficiency suppressed H3K27me3 and cell differentiation during neural tube development in mice.

S-adenosylmethionine (SAM) as a major methyl donor plays a key role in methylation modification in vivo, and its disorder was closely related to neural tube defects (NTDs). However, the exact mechanism between SAM deficiency and NTDs remained unclearly. Hence, we investigated the association between histone methylation modification and cell differentiation in NTDs mice induced by SAM deficiency.

Cycloleucine induces neural tube defects by reducing Pax3 expression and impairing the balance of proliferation and apoptosis in early neurulation.

S-adenosylmethionine (SAM) plays a critical role in the development of neural tube defects (NTDs). Studies have shown that the paired box 3 (Pax3) gene is involved in neural tube closure. However, the exact mechanism between Pax3 and NTDs induced by SAM deficiency remains unclear.

Three undescribed dihydrostilbene glycosides from leaves of Abel. And their anti-inflammatory activity.

Three previously unidentified dihydrostilbene glycosides, named oleiferaside A (), oleiferaside B (), and oleiferaside C (), were discovered through a phytochemical exploration on Abel. leaves. Additionally, nine known secondary metabolites () were also identified.

Identification of potential key ferroptosis- and autophagy-related genes in myelomeningocele through bioinformatics analysis.

Myelomeningocele is a common congenital anomaly associated with polygenic disorders worldwide. However, the intricate molecular mechanisms underlying myelomeningocele remain elusive. To investigate whether ferroptosis and ferritinophagy contribute to the pathomechanism of myelomeningocele, differentially expressed genes (DEGs) were identified as novel biomarker and potential treatment agents.

Phytochemical constituents from rhizomes of and their anti-inflammatory activity.

The phytochemical investigation on the rhizomes of (Dryopteridaceae) resulted in the discovery of one novel compound, drycrassirhizomamide A (), and one new natural product, drycrassirhizomamide B (), as well as four known isolates, ()-(-)--benzoylphenylalaninol (), blumenol A (), 8--glucosylnoreugenin (), and dryopteroside (). Their chemical structures were identified by NMR and mass spectroscopy. Compounds were determined to be 1,19-diethyl 10-oxo-2,9,11,18-tetraazanonadecanedioate and ,'-diethyl ,'-1,6-hexanediylbis[carbamate].

Research progress on aging mechanism and drugs and the role of stem cells in anti-aging process.

There have been many discussions on longevity from ancient times to the present day. In the Laozi, it is said, "Heaven and earth are long and enduring because they do not arise from themselves, so they can live forever." In Zhuangzi - Zai You, it is also said, "Keep your mental peace, and your body will be healthy.

Neuroprotective Effects of Savinin on LPS-Induced Neuroinflammation In Vivo via Regulating MAPK/NF-κB Pathway and NLRP3 Inflammasome Activation.

The traditional herb Oliv. is commonly used to treat inflammatory conditions including rheumatism, arthritis, and hepatitis, as well as mental fatigue and amnesia, according to traditional Chinese medicine (TCM) theory. Savinin is a natural lignan obtained from the roots of .

Facile immobilization of his-tagged Microbacterial esterase on Ni-SBA-15 with enhanced stability for efficient synthesis of key chiral intermediate of d-biotin.

A series of nickel-incorporated SBA-15 mesoporous molecular sieves (Ni-SBA-15) were prepared as support for the immobilization of his-tagged recombinant Microbacterium esterase. The Ni-SBA-15 could strongly and specific absorb the his-tagged esterase from cell disrupted supernatant. It was found that the nickel amount in Ni-SBA-15 has dramatic influence on the activity and thermo-stability of immobilized enzyme, while the kinds of nickel precursor had little effect on enzyme stability.