Research Progress of Drugs in Prevention and Treatment of Nephrolithiasis.

With the improvement of people's living standards,the incidence of nephrolithiasis is increasing year by year.Nephrolithiasis poses a serious threat to the patients due to the unclear etiology,complicated composition of stones,and high recurrence rate after surgery.As the research on the pathogenesis and pathophysiology of nephrolithiasis keeps deepening in recent years,researchers have made achievements in the drug treatment,which has become a hot topic for urologists.

The effect of magnetic order on the thermal transport properties of the intrinsic two-dimensional magnet 2H-VSe.

By using first-principles calculations combined with the phonon Boltzmann transport equation, in this work, we systematically investigate the effect of magnetic order on the phonon and thermal transport properties of the intrinsic two dimensional magnet 2H-VSe. The results show that 2H-VSe is dynamically stable in both paramagnetic and ferromagnetic phases, and the obvious discrepancy of characteristic frequencies of Raman-active phonon modes provides a reliable way to identify the magnetic phase. Meanwhile, our calculations also indicate that the magnetic order has a vital effect on the thermal transport properties.

Impact of adjuvant chemotherapy on T1N0M0 breast cancer patients: a propensity score matching study based on SEER database and external cohort.

Background: There is no clear consensus on the benefits of adjuvant chemotherapy for tumor-node-metastasis (TNM) stage T1 (T1N0M0) breast cancer (BC). Our study investigated the effects of adjuvant chemotherapy on T1N0M0 BC patients.

Methods: Seventy-five thousand one hundred thirty-nine patients diagnosed with T1N0M0 BC were selected from the Surveillance, Epidemiology, and End Results (SEER) database.

Dendritic organosilica nanospheres with large mesopores as multi-guests vehicle for photoacoustic/ultrasound imaging-guided photodynamic therapy.

Photodynamic therapy (PDT) is a minimally invasive treatment strategy that uses photosensitizers and light in combination with oxygen to generate cytotoxic singlet oxygen (O) to kill cancer cells by necrosis or apoptosis. However, the treatment effects are still not satisfactory because of the tumor hypoxia and the PDT-induced oxygen consumption. Here, we have successfully synthesized dendritic mesoporous organosilica nanoparticles (MONs) with large center-radial pore structure that can be used to simultaneously encapsulate indocyanine green (ICG, <1 nm) and macromolecule catalase (CAT, 2.

Expression and significance of miR-654-5p and miR-376b-3p in patients with colon cancer.

Background: The relationship between microRNAs, such as miR-654-5p and miR-376b-3p, and the prognosis of colon cancer has not been studied until now.

Aim: To evaluate the expression levels of miR-654-5p and miR-376b-3p and their clinical significance in colon cancer.

Methods: RT-qPCR was performed to evaluate miR-654-5p and miR-376b-3p expression in 34 pairs of colon cancer and adjacent noncancerous tissues.

Self-Assembled Polysaccharide-Diphenylalanine/Au Nanospheres for Photothermal Therapy and Photoacoustic Imaging.

Gold-based nanomaterials have attracted extensive interest for potential application in photothermal therapy (PTT) owing to their distinctive properties including high photothermal transduction, biocompatibility, and low cytotoxicity. Herein, assembled gold nanoparticle architecture-based photothermal conversion agents were synthesized by using polysaccharides (alginate dialdehyde, ADA) as both the cross-linker to induce self-assembly of diphenylalanine (FF) and the reducer for in situ reduction of Au ions into Au nanoparticles (Au NPs). The extinction spectrum of the obtained self-assembled ADA-FF/Au nanospheres was finely modulated into a near-infrared region by controlling the growth of Au NPs inside the assemblies.

Worse characteristics can predict survival effectively in bilateral primary breast cancer: A competing risk nomogram using the SEER database.

Objective: There is limited information from population-based cancer registries regarding prognostic features of bilateral primary breast cancer (BPBC).

Methods: Female patients diagnosed with BPBC between 2004 and 2014 were randomly divided into training (n = 7740) and validation (n = 2579) cohorts from the Surveillance, Epidemiology, and End Results Database. We proposed five various models.