[Populational characteristics of metabolic syndrome in open male population].

Objective: to assess prevalence of various clusters of metabolic syndrome (MS) in open male population aged 25- 64 years.

Methods: This cross sectional epidemiological study was conducted on a representative population sample formed from lists of male voters in one of administrative districts in Tumen. NCEP ATP III (2004) MS criteria were used in analysis.

[Associations of the prevalence of cardiovascular diseases with a high level of depression in the open population of an average urbanized Siberian town].

Aim: To reveal an association of the prevalence of coronary heart disease (CHD) and metabolic syndrome (MS) with a high level of depression in the open population of 25-64-year-old men in an average urbanized Siberian town.

Subjects And Methods: The survey was conducted on a representative sample formed from the voting list of 25-64-year-old men in one of the administrative districts of Tyumen. The standard WHO MONICA-psychosocial questionnaire was used to study associations of the prevalence of CHD and MS with a high level of depression within cardiologic screening.

[Rapid experimental rationale for a waste hazard class by cytotoxicity].

The paper presents the results of experimental and analytical studies substantiating a classification of waste hazard by the cytotoxicity indices. The authors have established a significant correlation between the substance toxicity values obtained in vivo and in vitro and show it possible to make an approximate forecast of the average lethal concentration of substances by the estimates made on cell cultures. The criteria for toxicological waste hazard, which are adequate to those for the hazards of chemicals by DL50, are given.

[The specificity of interaction between the complement and the lipopolysaccharide with a low activity of the complement (hypothesis)].

Interactions between the complement with a low activity and the lipopolysacharide (LPS) with an extensive concentration range were experimentally investigated in vitro. A model was suggested that provides an explanation to the concentration-related dependence. The complement and LPS were shown, under certain conditions, to form the membrane-attacking complexes, which are not bound with the bacterium membrane and which can lyse any cells.

[Evaluation and prognosis of patients' health status in postop period].

An estimation of the patient's state and the prognosis can be made at the postoperative period on the basis of results of the assessment of complement activity, blood cell hemolysate activity, filtration of serum and urine. Of the greatest clinical significance for the estimation of the patient's state is complement activity and toxicity of urine.

[Toxicological screening of biological fluids].

Analysis of the results of evaluation of the complement activity, toxicity of the urine, low molecular weight fraction of the blood, and blood cell hemolysis confirmed the suggested simplified model of endotoxicosis and showed that evaluation of the complement activity and urine toxicity is sufficient for tentative laboratory diagnosis of endotoxicosis. Proceeding from these data it is possible to evaluate the patient's status and predict the disease outcome. Laboratory diagnosis is made using a biological test system and toxicity analyzer.

[A new method for total complement activity analysis and its clinical significance].

A test system consisting of a short-term suspension culture of mobile cells (bovine semen) is suggested for evaluating the complement activity. A simple and effective rapid method for evaluating the complement activity is based on the use of this system. Clinical application of this method helps evaluate the disease severity and predict the patient's condition in various diseases.

[Spermatic index of intoxication, a method of the assessment of blood toxicity].

The article deals with a new method for determining the degree of intoxication in patients with peritonitis of various etiology. Bull sperm cells were used as the test-object. The degree of intoxication is judged according to the ratio of the mean life time of the spermatozoa in the studied filtrate, obtained from the blood serum of patients with peritonitis by filtration through polysulfone membranes with a pass band of up to 70,000 daltons, to the life time in a control glucose-nitrate solution.

[An experimental biotechnical system for determining an index of toxicity].

The system of bioengineering for determination of toxicity index with bovine spermatozoal suspension as a primary transducer was developed. The toxicity index is determined according to a change in spermatozoal suspension mobility defined with the help of an optoelectronic device. The system of bioengineering is used for determination of toxicity index of polymers for medical applications.

[Toxicologic evaluation of individual chemical compounds and complex mixtures using a motile cell test object].

The possibility of quantitative prognosis of chemical compounds and complex mixtures toxicity by means of a biotechnical system with suspension of bull spermatozoa sensor was investigated. The concentration of some chemical compounds, inhibiting by half spermatozoa motility has been experimentally determined. A correlation between the values determined and acute toxicity of the compounds tested has been established.