Better outcome of ablation for sustained outflow-tract ventricular tachycardia when tachycardia is inducible.

Aims: In patients presenting with spontaneous sustained ventricular tachycardia (VT) from the outflow-tract region without overt structural heart disease ablation may target premature ventricular contractions (PVCs) when VT is not inducible. We aimed to determine whether inducibility of VT affects ablation outcome.

Methods And Results: Data from 54 patients (31 men; age, 52 ± 13 years) without overt structural heart disease who underwent catheter ablation for symptomatic sustained VT originating from the right- or left-ventricular outflow region, including the great vessels.

Surgical cryoablation for ventricular tachyarrhythmia arising from the left ventricular outflow tract region.

Background: Ventricular arrhythmias (VAs) from the left ventricular outflow tract (LVOT) region can be inaccessible for ablation because of epicardial fat or overlying coronary arteries.

Objective: We describe surgical cryoablation of this type of VA.

Methods: From March 2009 to 2014, 190 consecutive patients with VAs originating from the LVOT underwent ablation at our institution.

Correlates and prognosis of early recurrence after catheter ablation for ventricular tachycardia due to structural heart disease.

Background: Catheter ablation for ventricular tachycardia (VT) from structural heart disease has a significant risk of recurrence, but the optimal duration for in-hospital monitoring is not defined. This study assesses the timing, correlates, and prognostic significance of early VT recurrence after ablation.

Methods And Results: Of 370 patients (313 men; aged 63.

Ventricular arrhythmias near the distal great cardiac vein: challenging arrhythmia for ablation.

Background: Catheter ablation for ventricular arrhythmia (VA) near the distal great cardiac vein (GCV) is often challenging, and data are limited.

Methods And Results: Analysis was performed in 30 patients (19 men; age, 52.8±15.

Priming characteristics of peptide mimotopes of carbohydrate antigens.

Immunization with peptide mimetics of carbohydrate antigens can induce functional carbohydrate-reactive antibodies. Here, we examine the immune characteristics of alternative approaches in prime and boost strategies using glycosylated HIV-1 envelope protein and model tumor associated carbohydrate antigens. Our results indicate that peptide mimotopes either in a DNA or carrier-conjugated format can induce comparable levels of IgM and IgG.