New technique for endobronchial targeting of the segmental bronchus during thoracoscopic segmentectomy.

During thoracoscopic pulmonary segmentectomy, identification of the target segmental bronchus can occasionally be difficult. We devised a new method to overcome this difficulty. Immediately before surgery, the target segmental bronchus was marked with indocyanine green using bronchoscopy and identified intraoperatively using near-infrared fluorescence thoracoscopic imaging.

Identifying the intersegmental line using a concave portion during upper lobe apical segmentectomies.

Objectives: The hilum approach of intersegmental division along the intersegmental vein is difficult in the case with central vein type during upper lobe apical segmentectomy. We aimed to explore the possibilities of the simple intersegmental division used the concave portion of the apical pleura with computed tomography images.

Methods: We evaluated computed tomography images of patients who underwent anatomical lung resection between June 2020 and April 2024.

Administration of a Selective Antagonist for Pituitary Adenylate Cyclase-Activating Polypeptide Receptor in the Hippocampus Causes Anxiolytic Effects in the Male Rat.

Pituitary adenylate cyclase-activating polypeptide (PACAP) affects rodents' stress-related behaviors, such as anxiety-like behavior or fear conditioning. However, previous studies have investigated the effect of intracerebroventricular, but not hippocampal, injection of this PAC1R-selective antagonist (PACAP-6-38) on anxiety-like behavior. However, it has been reported that administration of PACAP-6-38 to the dorsal hippocampus reduces the fear response in a fear conditioning test.

Improvement of Adsorption Capacity by Refined Encapsulating Method of Activated Carbon into the Hollow-Type Spherical Bacterial Cellulose Gels for Oral Absorbent.

To reduce the risk of adsorption of granular activated carbon (AC) in the gastrointestinal tract, we successfully prepared a hollow-type spherical bacterial cellulose gel encapsulated with AC (ACEG) and evaluated its pH tolerance and adsorption capacity. The bacterial cellulose gel membrane of ACEG features a three-dimensional mesh structure of cellulose fibers, allowing the selective permeation of substances based on their size. In this study, the preparation method of ACEGs was investigated, and the indole saturation adsorption capacity of the obtained gel was measured.

Adsorption Capacity of Activated Carbon-Encapsulated Hollow-Type Spherical Bacterial Cellulose Gels for Uremic Toxins in a Simulated Human Gastrointestinal Environment.

To reduce the risk of the adsorption of granular activated carbon in the gastrointestinal tract, we successfully produced a hollow-type spherical bacterial cellulose (HSBC) gel containing activated carbon with a particle size of 6 μm. In this study, the aim of which was to develop an effective formulation, we evaluated the stability of activated-carbon-encapsulating HSBC gels under various pH conditions. Activated-carbon-encapsulating HSBC gels (ACEGs) retained the activated carbon without leaking when subjected to agitation in acidic or basic environments.

Salivary metabolites as potential predictive biomarkers for lung surgery complications: a retrospective cross-sectional study.

Purpose: Saliva is often used as a tool for identifying systemic diseases because of the noninvasive nature of its collection. Moreover, salivary metabolites can be potential predictive factors for postoperative survival. We conducted the present study to establish whether salivary metabolites can function as predictive biomarkers for lung surgery complications.

Expression and characterization of α-1,3-glucanase from Paenibacillus alginolyticus NBRC15375, which is classified into subgroup 2 (minor group) of GH family 87.

Bacterial α-1,3-glucanase, classified as glycoside hydrolase (GH) family 87, has been divided into 3 subgroups based on differences in gene sequences in the catalytic domain. The enzymatic properties of subgroups 1 and 3 of several bacteria have been previously investigated and reported; however, the chemical characterization of subgroup 2 enzymes has not been previously conducted. The α-1,3-glucanase gene from Paenibacillus alginolyticus NBRC15375 (PaAgl) belonging to subgroup 2 of GH family 87 was cloned and expressed in Escherichia coli.

Dual-portal robotic-assisted thoracic surgery (DRATS) as a reduced port RATS: early experiences in three institutions in Japan.

Background: Robotic-assisted thoracic surgery (RATS) has gained increasing interest in recent years, with most procedures performed using the conventional multiportal approach. Uniportal RATS (URATS) approaches have recently been reported in the pursuit of minimally invasive procedures. However, URATS requires specific skills.

Learning Curve for Thoracoscopic Individual Basilar Segmentectomy: 18-Year Experience.

Background: Thoracoscopic anatomical individual basilar segmentectomy remains challenging owing to the deep intraparenchymal location of the hilar structures and anatomical variations. We analyzed and reported the experience and progress of thoracoscopic anatomical individual basilar segmentectomy at our university hospital.

Methods: We retrospectively examined the patients who underwent anatomical basilar segmentectomy at our institution from January 2004 to December 2021.

[Minimally Invasive Surgery for Mediastinal Diseases in Our Institute:Innovations and Surgical Practice].

Since the early 1990s, minimally invasive surgery has been introduced in many surgical fields. The progress of technology and increased interest in minimally invasive surgery has led to innovation from surgery with a large incision to complete thoracoscopic surgery in many facilities. We started thoracoscopic mediastinal surgery in 1997 and robot-assisted mediastinal surgery in 2021.

Residual middle lobectomy after right upper or lower lobectomy: indications and outcome.

Objectives: Residual middle lobectomy after upper lobectomy and lower lobectomy differs in their indications and perioperative outcomes. Therefore, we aimed to evaluate the indications and perioperative outcomes of residual middle lobectomy after upper and lower lobectomy.

Methods: The data of 14 patients who underwent residual middle lobectomy after upper or lower lobectomy between January 1997 and December 2021 were extracted and analyzed.

The preoperative assessment of thoracic wall adhesions using four-dimensional computed tomography.

Objective: Pleural adhesions are challenging during lung cancer surgery and may be associated with a long surgery time and excessive blood loss due to pleural adhesiolysis. We used preoperative four-dimensional computed tomography to quantitatively assess parietal pleural adhesions and determine its diagnostic accuracy.

Methods: A total of 216 patients with lung cancer underwent four-dimensional computed tomography during the study period.

Thoracoscopic "cut-through" segmentectomy for small-sized lung cancer in a deep central location.

The use of segmentectomy and subsegmentectomy for the management of lung lesions is well established. However, the use of subsegmentectomy for deep seated lesions in the upper lobe is difficult because of sufficient surgical margins. Here, we present a patient whose lung lesion was in a deep central area and at the borders of three segments in the upper lobe of the right lung.

Thoracoscopic anatomical individual basilar segmentectomy.

Objectives: Thoracoscopic anatomical single or combined anatomical individual basilar segmentectomy, including subsegmentectomy, is technically challenging due to variations and the deep location of vessels and bronchi in the parenchyma. However, the long-term perioperative outcomes of various anatomical subsegmentectomy approaches have not been reported. Thus, we investigated the effectiveness of thoracoscopic basilar segmentectomy.

Completion lobectomy after anatomical segmentectomy.

Objectives: Completion lobectomy (CL) after anatomical segmentectomy in the same lobe can be complicated by severe adhesions around the hilar structures and may lead to fatal bleeding and lung injury. Therefore, we aimed to investigate the perioperative outcomes of CL after anatomical segmentectomy.

Methods: Among 461 patients who underwent anatomical segmentectomy (thoracotomy, 62 patients; thoracoscopic surgery, 399 patients) between January 2005 and December 2019, data of patients who underwent CL after segmentectomy were extracted and analysed in this study.

Effect of the conformer distribution on the properties of amorphous organic semiconductor films for organic light-emitting diodes.

With the remarkable improvement in the electrical and optical properties of organic light-emitting diodes (OLEDs) in recent years, the details of the higher-order structure of vacuum-deposited amorphous organic films and its formation mechanism need to be understood. In particular, to clarify the effect of the higher-order structure on the film properties, it is necessary to analyze the molecular aggregation states in the vacuum-deposited amorphous films. Toward their deep understanding, the higher-order structure and film properties have often been discussed with relation to the surface diffusion and structural relaxation of the molecules immediately after deposition on the film surface.

Transdermal electroosmotic flow generated by a porous microneedle array patch.

A microneedle array is an attractive option for a minimally invasive means to break through the skin barrier for efficient transdermal drug delivery. Here, we report the applications of solid polymer-based ion-conductive porous microneedles (PMN) containing interconnected micropores for improving iontophoresis, which is a technique of enhancing transdermal molecular transport by a direct current through the skin. The PMN modified with a charged hydrogel brings three innovative advantages in iontophoresis at once: (1) lowering the transdermal resistance by low-invasive puncture of the highly resistive stratum corneum, (2) transporting of larger molecules through the interconnected micropores, and (3) generating electroosmotic flow (EOF).

Laparoscopic surgery for urachal remnants in pubescent children: a case series.

Background: Various techniques are applied in laparoscopic surgery for the treatment of urachal remnants, which are less invasive and associated with lower morbidity. We herein report a case series in which we treated urachal remnants and medial umbilical ligaments using a laparoscopic approach.

Case Presentation: From 2015 to 2019, seven patients (male, n = 5; female, n = 2) with a urachal remnant were treated by laparoscopic surgery in our institute.

Evaluation of effects of perioperative oral care intervention on hospitalization stay and postoperative infection in patients undergoing lung cancer intervention.

Purpose: This retrospective study investigated the effect of perioperative oral care intervention on postoperative outcomes in patients undergoing lung cancer resection, in terms of the length of postoperative hospital stay and the incidence of postoperative respiratory infections.

Methods: In total, 585 patients underwent lung resection for lung cancer, 397 received perioperative oral care intervention, whereas the remaining 188 did not. This study retrospectively investigated the demographic and clinical characteristics (including postoperative complications and postoperative hospital stay) of each group.