Publications by authors named "Kaitlyn Petentler"
Article Synopsis
- The study investigates the role of Frizzled5 (Fzd5), a receptor in the Wnt signaling pathway, in maintaining the health and function of intestinal epithelial cells.
- Deleting Fzd5 in specific intestinal stem cells impairs their ability to renew and generate new cells, affecting different aspects of epithelial structure but not overall integrity.
- Comprehensive analysis reveals that Fzd5 regulates gene expression by influencing chromatin accessibility in stem and progenitor cells, highlighting its crucial function in intestinal epithelial plasticity.
Previous studies of hematopoietic stem cells (HSCs) primarily focused on single cell-based niche models, yielding fruitful but conflicting findings . Here we report our investigation on the fetal liver (FL) as the primary fetal hematopoietic site using spatial transcriptomics. Our study reveals two distinct niches: the portal-vessel (PV) niche and the sinusoidal niche.
View Article and Find Full Text PDFSpatial transcriptomics maps RNA molecules to the location in a tissue where they are expressed. Here we document the use of Slide-SeqV2 to visualize gene expression in the mouse olfactory bulb (OB). This approach relies on spatially identified beads to locate and quantify individual transcripts.
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