Digoxin and its Na/K-ATPase-targeted actions on cardiovascular diseases and cancer.

Na/K-ATPase (NKA) is a plasma membrane ion-transporting protein involved in the generation and maintenance of Na and K gradients across the cell membrane, which can produce a driving force for the secondary transport of metabolic substrates. NKA also regulates intracellular calcium that is responsible for modulating numerous cellular processes, while it interacts with many other proteins and functions as a signal transducer, with several signaling pathways being involved. Thus, NKA has become an important target for the treatment of human diseases.

Development of Potential Therapeutic Agents from Black Elderberries (the Fruits of L.).

Elderberry ( L.) is a widespread deciduous shrub, of which the fruits (elderberries) are used in the food industry to produce different types of dietary supplement products. These berries have been found to show multiple bioactivities, including antidiabetic, anti-infective, antineoplastic, anti-obesity, and antioxidant activities.