Publications by authors named "Kaitlyn J Loubet-Senear"
Extensive subclonal mutational diversity in human colorectal cancer and its significance.
Proc Natl Acad Sci U S A
December 2019
Article Synopsis
- Human colorectal cancers have both clonal mutations, which are common and drive cancer growth, and subclonal mutations that are random and increase tumor diversity, making treatment resistance more likely.
- A new sequencing method, duplex sequencing, was used to measure these subclonal mutations in CRCs with high precision, revealing a surprisingly high mutation rate.
- The findings suggest that every cell in a tumor likely has some mutations, meaning current models of tumor evolution that assume one mutation per cell may not be accurate, especially in larger tumors.