Comparison of Bayesian-derived and first-order analytic equations for calculation of vancomycin area under the curve.

Introduction: Consensus guidelines recommend targeting a vancomycin area under the curve to minimum inhibitory concentration (AUC :MIC) ratio of 400-600 to improve therapeutic success and reduce nephrotoxicity. Although guidelines specify either Bayesian software or first-order equations may be used to estimate AUC , there are currently no large studies directly comparing these methods.

Objective: To compare calculated vancomycin AUC using first-order equations with two-drug concentrations at steady state to Bayesian two- and one-concentration estimations.