Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain.

Neonatal seizures disrupt normal synaptic maturation and often lead to later-life epilepsy and cognitive deficits. During early life, the brain exhibits heightened synaptic plasticity, in part due to a developmental overabundance of Ca1.2 L-type voltage gated calcium (Ca) channels (LT-VGCCs) and Ca-permeable AMPARs (CP-AMPARs) lacking GluA2 subunits.