Loss of Delays Mammary Tumor Development and Impairs Metastasis.

Matrix-remodeling-associated protein 8 or MXRA8 is a transmembrane protein that can bind arthritogenic alpha viruses like the Chikungunya virus and provide viral entry into cells. MXRA8 can also interact with integrin β3 and thus possibly regulate cell-cell interactions and binding to the extracellular matrix. While has been associated with reduced survival in patients with colorectal and renal clear cell cancers, the role of in breast cancer remains largely unexplored.

Elevated Expression of miR-200c/141 in MDA-MB-231 Cells Suppresses Levels and Impairs Breast Cancer Growth and Metastasis In Vivo.

Breast cancer cells with mesenchymal characteristics, particularly the claudin-low subtype, express extremely low levels of miR-200s. Therefore, this study examined the functional impact of restoring miR-200 expression in a human claudin-low breast cancer cell line MDA-MB-231. MDA-MB-231 cells were stably transfected with a control vector (MDA-231EV) or the miR-200c/141 cluster (MDA-231c141).