Development of White Cabbage, Coffee, and Red Onion Extracts as Natural Phosphodiesterase-4B (PDE4B) Inhibitors for Cognitive Dysfunction: and Studies.

Human cognition fundamentally depends on memory. Alzheimer's disease exhibits a strong correlation with a decline in this factor. Phosphodiesterase-4 B (PDE4B) plays a crucial role in neurodegenerative disorders, and its inhibition is one of the promising approaches for memory enhancement.

The role of Phosphodiesterase-1 and its natural product inhibitors in Alzheimer's disease: A review.

Phosphodiesterase-1 (PDE1) is a versatile enzyme that has surprisingly received considerable attention as a possible therapeutic target in Alzheimer's disease (AD) because it maintains the homeostasis of 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) in the brain. 3',5'-cyclic adenosine monophosphate and 3',5'-cyclic guanosine monophosphate are the two key second messengers that regulate a broad range of intracellular processes and neurocognitive functions, specifically memory and cognition, associated with Alzheimer's disease. However, the lack of available selective drugs on the market poses challenges to identifying the beneficial effects of natural products.

The impact of heart disease risk factors on the age of 30 to 80 Years Old Patients- Residing in and around Khulna district of Bangladesh.

Objectives: The present study aimed to evaluate the Impact of heart disease risk factors on the age of 30-80 years' old patients-residing in and around Khulna District of Bangladesh. Data collection took place in April, 2017 to October, 2017.

Methods: The research was characterized by questionnaires on the basis of gender, age, BMI, physical activity, working pattern, family history, fast food consumption, smoking habit and Total cholesterol test.