Publications by authors named "Kaisi Yang"
Background: Histone deacetylase (HDAC) is a potential target for Colorectal Cancer (CRC) molecular target therapy, dehydroharmine derivative ZDLT-1 was designed to inhibit CRC cell proliferation by inhibiting HDAC target. This study aimed to explore the effect of ZDLT-1 could induce apoptosis in CRC in vitro and in vivo, and determine the mechanism of ZDLT-1.
Methods: First, MTT assay, colony formation, wound healing, Transwell assay, Hoechst33342 staining and Annexin V-FITC/PI double staining assay were used to investigate the in vitro effect of ZDLT-1.
Article Synopsis
- The study investigates the effectiveness and safety of various PI3K/AKT inhibitors in treating cancers, focusing on comparing their efficacy across different cancer types.
- An analysis of 34 studies with 6,710 patients revealed that these inhibitors are particularly effective for mutant cancers, although they often have poor safety profiles.
- Specifically, capivasertib was noted as effective for solid tumors like breast cancer, while idelalisib was effective for hematological cancers such as chronic lymphocytic leukemia.
Background: Transarterial chemoembolization (TACE) is a common treatment for hepatocellular carcinoma (HCC), but the best therapeutic agent for TACE treatment has not been determined. The neutrophil/lymphocyte ratio (NLR) is a systemic immune system marker; however, the ability of the NLR to predict the prognosis of patients with HCC is unknown, and no studies have been conducted to determine the most appropriate TACE regimen for HCC patients with different NLRs.
Methods: The PubMed, Embase, Web of Science, and CNKI databases were searched through May 28, 2023.
ZLDI-8 is an A disintegrin and metalloproteinase domain 17 (ADAM17) inhibitor that suppresses the shedding of Notch1 to the Notch1 intracellular domain (NICD). In previous studies, we found that ZLDI-8 was able to sensitize HCC to sorafenib, but the mechanism of action remains unclear. The sensitizing effects of ZLDI-8 were tested both in vitro and in vivo.
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- - The study investigates the effectiveness and safety of anti-TNF-α monoclonal antibodies (adalimumab and infliximab) combined with proactive therapeutic drug monitoring (TDM) for patients with inflammatory bowel disease (IBD).
- - Results from 13 included studies showed that proactive TDM significantly improved clinical remission rates, reduced surgery needs, and decreased adverse events among patients, particularly those treated with adalimumab.
- - The authors conclude that proactive TDM is especially beneficial for IBD patients treated with adalimumab, suggesting a need for tailored monitoring strategies based on the patient's treatment type.
Separating sensitive characteristic signals from original vibration data is an important challenge for rolling bearing fault diagnosis. Because it is difficult to obtain large number of damaged bearings, Rolling bearing fault datasets are often small sample datasets. For the classification of small sample rolling bearing fault datasets, we propose a coupling vibration data classification method based on triplet embedding.
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