The structure modification with glucosamine of glycyrrhetinic acid extracted from Glycyrrhiza uralensis Fisch offal and mechanism of action based on network pharmacology and molecular docking against type II diabetes.

In order to improve the solubility and hypoglycemic activity of glycyrrhetinic acid (GA), the active mechanism of action of new compounds was explored. A novel 2-(N-3-acetylglycyrrhetinoyl)-N-glucopyranosyl-2-acetamide (compound 9) was synthesized by adding glucosamine (GlcN) to the C-30 carboxyl group of GA, and the hypoglycemic activity mechanism of compound 9 was explored by network pharmacology and molecular docking. The results showed that the solubility of compound 9 was better than GA, and the α-glucosidase inhibitory effect of compound 9 (IC50 = 0.

Isolation, structural characterization and immunomodulatory activity on RAW264.7 cells of a novel exopolysaccharide of Dictyophora rubrovalvata.

Fungal polysaccharides have been explored by many for both structural studies and biological activities, but few studies have been done on the extracellular polysaccharides of Dictyophora rubrovalvata, so a new exopolysaccharide was isolated from Dictyophora rubrovalvata and its structure and its immunological activity were investigated. The crude exopolysaccharide (EPS) was purified by DEAE52 cellulose and Sephadex G-200 to obtain a new acidic polysaccharide (DR-EPS). DR-EPS (2.