Publications by authors named "Kaiser Y"
Article Synopsis
- The study focuses on Tc-fucoidan, a compound derived from brown algae, which targets P-selectin for early identification of thrombosis.
- In the safety assessment involving ten healthy volunteers, Tc-fucoidan was well tolerated with no adverse effects and demonstrated reliable uptake in human thrombi in gamma counting experiments.
- Although the results showed potential for imaging thrombi in certain cases, the overall findings do not support further clinical use of Tc-fucoidan for diagnosing deep vein thrombosis (DVT), suggesting exploration of alternative P-selectin tracers instead.
Article Synopsis
- The trans intestinal cholesterol excretion (TICE) pathway is a strategy to lower LDL cholesterol by promoting the direct excretion of cholesterol from enterocytes into feces, which was previously stimulated in mice using hydrophilic bile acids.* -
- A clinical trial tested whether the bile acid ursodeoxycholic acid (UDCA) could increase fecal cholesterol excretion in humans, involving 20 male participants who received either UDCA or a placebo after a run-in with ezetimibe.* -
- Results showed that while UDCA did increase the hydrophilicity of bile acids, it did not elevate fecal neutral sterols nor decrease LDL cholesterol levels, indicating TICE may not be influenced by bile acid hydroph
Article Synopsis
- Inflammation contributes to the development of atherosclerotic cardiovascular disease, and the study aims to explore how inflammatory markers relate to changes in coronary plaque volume measured by coronary CT angiography (CCTA).
- The research involved 161 patients aged 40 and above with stable coronary artery disease, measuring inflammatory markers like IL-6 at the start, and assessing plaque volumes after a year.
- Results showed that higher IL-6 levels were linked to significant increases in total and noncalcified plaque volume, suggesting that targeting IL-6 could help manage plaque progression and cardiovascular risks.
Importance: Lipoprotein(a) (Lp[a]) is a causal risk factor for cardiovascular disease; however, long-term effects on coronary atherosclerotic plaque phenotype, high-risk plaque formation, and pericoronary adipose tissue inflammation remain unknown.
Objective: To investigate the association of Lp(a) levels with long-term coronary artery plaque progression, high-risk plaque, and pericoronary adipose tissue inflammation.
Design, Setting, And Participants: This single-center prospective cohort study included 299 patients with suspected coronary artery disease (CAD) who underwent per-protocol repeated coronary computed tomography angiography (CCTA) imaging with an interscan interval of 10 years.
Background: Despite advances in treatment for brain metastases (BMs), the prognosis for recurrent BMs remains poor and requires further research to advance clinical management and improve patient outcomes. In particular, data addressing the impact of tumor volume and surgical resection with regard to survival remain scarce.
Methods: Adult patients with recurrent BMs between December 2007 and December 2022 were analyzed.
Aims/hypothesis: Inflammation is a core component of residual cardiovascular risk in type 2 diabetes. With new anti-inflammatory therapeutics entering the field, accurate markers to evaluate their effectiveness in reducing cardiovascular disease are paramount. Gallium-68-labelled DOTATATE (Ga-DOTATATE) has recently been proposed as a more specific marker of arterial wall inflammation than F-fluorodeoxyglucose (F-FDG).
View Article and Find Full Text PDFObjective: The purpose of this study was to investigate and classify the molecular subtypes of high-grade ductal carcinoma in situ (DCIS) and identify possible high-risk subtypes. The heterogenicity of DCIS with variable clinical and histopathological presentations has been recognized. Nevertheless, only histopathological grading and diameter are currently implemented in clinical decision-making following the diagnosis of DCIS.
View Article and Find Full Text PDFAortic Valve Calcium in Relation to Subclinical Cardiac Dysfunction and Risk of Heart Failure.
Circ Cardiovasc Imaging
March 2023
Background: The link between (mild) aortic valve calcium (AVC) with subclinical cardiac dysfunction and with risk of heart failure (HF) remains unclear. This research aims to determine the association of computed tomography-assessed AVC with echocardiographic measurements of cardiac dysfunction, and with HF in the general population.
Methods: We included 2348 participants of the Rotterdam Study cohort (mean age 68.
Serum lipoprotein(a) and bioprosthetic aortic valve degeneration.
Eur Heart J Cardiovasc Imaging
May 2023
Article Synopsis
- - The study investigates the relationship between serum lipoprotein(a) [Lp(a)] levels and the degeneration of bioprosthetic aortic valves, given that Lp(a) is linked to aortic stenosis risk.
- - Researchers conducted a detailed analysis using echocardiography and imaging techniques on 97 patients with bioprosthetic valves over two years, focusing on Lp(a) levels and valve health metrics.
- - Results indicate that serum Lp(a) concentrations do not significantly influence the progression or degeneration of bioprosthetic aortic valves, suggesting other factors may play a more critical role.
Molecular Imaging of Aortic Valve Stenosis with Positron Emission Tomography.
Pharmaceuticals (Basel)
June 2022
Aortic valve stenosis (AVS) is an increasingly prevalent disease in our aging population. Although multiple risk factors for AVS have been elucidated, medical therapies capable of slowing down disease progression remain unavailable. Molecular imaging technologies are opening up avenues for the non-invasive assessment of disease progression, allowing the assessment of (early) medical interventions.
View Article and Find Full Text PDFAim: Lipoprotein(a) [Lp(a)] is a potential causal factor in the pathogenesis of aortic valve disease. However, the relationship of Lp(a) with new onset and progression of aortic valve calcium (AVC) has not been studied. The purpose of the study was to assess whether high serum levels of Lp(a) are associated with AVC incidence and progression.
View Article and Find Full Text PDFArticle Synopsis
- Severe obstructive sleep apnea (OSA) increases cardiovascular disease risk, potentially due to heightened sympathetic activity and inflammation.
- A study compared untreated severe OSA patients with mild OSA patients, measuring heart rate variability (HRV), baroreflex sensitivity (BRS), and spleen activity using advanced imaging techniques.
- Results indicated severe OSA patients had lower BRS and higher splenic activity, suggesting a distinct physiological profile that may influence atherosclerosis, necessitating further research on the effects of OSA treatment.
Article Synopsis
- Lipoprotein(a) [Lp(a)] is linked to a higher risk of heart attacks, but the exact reasons for this connection are not fully understood.
- The study aimed to determine if high levels of Lp(a) lead to worse plaque progression in patients with advanced coronary artery disease.
- Results showed that patients with high Lp(a) levels had significantly more progression of low-attenuation plaques (indicative of necrotic core) compared to those with low levels, suggesting that Lp(a) may play a role in accelerating this particular type of plaque growth.
Article Synopsis
- Thrombosis significantly impacts mortality for COVID-19 patients, and it may be linked to hypercoagulability driven by interleukin (IL)-6, which also raises lipoprotein(a) [Lp(a)] levels.
- In a study of 219 hospitalized COVID-19 patients, researchers found that Lp(a) increased by an average of 16.9 mg/dl, with higher increases correlating with a greater incidence of venous thromboembolism (VTE) events.
- The study concluded that elevated Lp(a) levels are closely associated with VTE in COVID-19 patients, suggesting that increased Lp(a) may contribute to a higher risk of thrombotic events during hospitalization.
Aims: To validate the reported increased atherosclerotic cardiovascular disease (ASCVD) risk associated with very high lipoprotein(a) [Lp(a)] and to investigate the impact of routine Lp(a) assessment on risk reclassification.
Methods And Results: We performed a cross-sectional case-control study in the Amsterdam UMC, a tertiary hospital in The Netherlands. All patients in whom a lipid blood test was ordered between October 2018 and October 2019 were included.
Objective: To assess whether patients with aortic valve stenosis (AS) with elevated lipoprotein(a) (Lp(a)) are characterised by increased valvular calcification activity compared with those with low Lp(a).
Methods: We performed F-sodium fluoride (F-NaF) positron emission tomography/CT in patients with mild to moderate AS (peak aortic jet velocity between 2 and 4 m/s) and high versus low Lp(a) (>50 mg/dL vs <50 mg/dL, respectively). Subjects were matched according to age, gender, peak aortic jet velocity and valve morphology.
Aim: Preclinical work indicates that low-density lipoprotein cholesterol (LDL-C) not only drives atherosclerosis by directing the innate immune response at plaque level but also augments proinflammatory monocyte production in the bone marrow (BM) compartment. In this study, we aim to unravel the impact of LDL-C on monocyte production in the BM compartment in human subjects.
Methods And Results: A multivariable linear regression analysis in 12 304 individuals of the EPIC-Norfolk prospective population study showed that LDL-C is associated with monocyte percentage (β = 0.
Background: Elevated Lp(a) (Lipoprotein(a)) levels are associated with coronary artery disease (CAD), ischemic stroke (IS), and calcific aortic valve stenosis (CAVS). Studies investigating the association between Lp(a) levels and these diseases in women have yielded inconsistent results.
Methods: To investigate the association of Lp(a) with sex-specific cardiovascular outcomes, we determined the association between genetically predicted Lp(a) levels (using 27 single nucleotide polymorphisms at the locus) and hepatic expression (using 80 single nucleotide polymorphisms at the locus associated with mRNA expression in liver samples from the Genotype-Tissue Expression dataset) on CAD, IS, and CAVS using individual participant data from the UK Biobank: 408 403 participants of European ancestry (37 102, 4283, and 2574 with prevalent CAD, IS, and CAVS, respectively).
Objectives: To investigate the prevalence and quantity of aortic valve calcium (AVC) in two large cohorts, stratified according to age and lipoprotein(a) (Lp(a)), and to assess the association between Lp(a) and AVC.
Methods: We included 2412 participants from the population-based Rotterdam Study (52% women, mean age=69.6±6.
Objectives: Recent reports suggest a high prevalence of hypertension and diabetes in COVID-19 patients, but the role of cardiovascular disease (CVD) risk factors in the clinical course of COVID-19 is unknown. We evaluated the time-to-event relationship between hypertension, dyslipidaemia, diabetes and COVID-19 outcomes.
Design: We analysed data from the prospective Dutch CovidPredict cohort, an ongoing prospective study of patients admitted for COVID-19 infection.