Publications by authors named "Kaiser J Loell"
Article Synopsis
- The activity of cis-regulatory elements (CREs) is influenced by the sequence context of transcription factor binding sites (TFBSs), with the CRX TF playing a key role in rod photoreceptors.
- CRX sites can positively enhance CRE activity, but multiple CRX sites may lead to repression due to negative interactions between them.
- The presence of other TFBSs can help mitigate these negative interactions, indicating that a diverse range of TFBSs is needed for enhancers to function effectively.
The pioneer factor hypothesis (PFH) states that pioneer factors (PFs) are a subclass of transcription factors (TFs) that bind to and open inaccessible sites and then recruit non-pioneer factors (non-PFs) that activate batteries of silent genes. The PFH predicts that ectopic gene activation requires the sequential activity of qualitatively different TFs. We tested the PFH by expressing the endodermal PF FOXA1 and non-PF HNF4A in K562 lymphoblast cells.
View Article and Find Full Text PDF