Survival following coronary artery bypass grafting in patients with severe angina pectoris (CASS). An observational study.

This observational study evaluates the effects of the severity of angina pectoris and the treatment method upon the survival of 4,209 patients in the Coronary Artery Surgery Study registry. In this nonrandomized study, these patients met the criteria used in the Coronary Artery Surgery Study randomized trial, except for the degree of angina pectoris and the method of selection of treatment. The 5 year survival rate was greater than or equal to 93% in patients with Class I and II angina pectoris and normal left ventricular function, regardless of the number of involved vessels or treatment received.

Simultaneous measurement of ventricular fluid and fontanelle pressure in neonates and infants with hydrocephalus.

Simultaneous measurement of fontanelle and ventricular fluid pressure was performed during 1-2 hours in 17 neonates and infants with hydrocephalus at a mean age of 7 weeks on 19 occasions. The fontanelle pressure recorded by a Ladd sensor was on the average 1.1 mmHg lower than the ventricular fluid pressure and differed from it by a standard deviation of +/- 3.

Intraoperative myocardial protection: a comparison of blood and asanguineous cardioplegia.

Cardiac arrest was achieved in 84 patients using asanguineous cardioplegia and in 97 patients using cold blood potassium cardioplegia. The patient groups were similar in age, sex ratio, and preoperative risk factors. Other than the cardioplegic solution used, the conduct of each operation was identical.

[Hematologic changes in rats following exposure to dichlorvos].

Two different experiments on rats were carried out: an acute intoxication causing clinical symptoms and a subchronical intoxication without any symptoms. After the acute experiment an increase of hemoglobin- and hematocrite values as well as of the mean corpuscular hemoglobin concentration was found. These differences are interpreted to be an increased erythropoiesis after hypoxia.

The importance of biventricular failure in patients with postoperative cardiogenic shock.

To evaluate the importance of severe biventricular failure in patients with postcardiotomy ventricular failure, we analyzed the data from 30 patients treated with ventricular assist devices (VADs) over a five-year period. All patients had profound postoperative ventricular failure refractory to drugs and an intraaortic balloon (IAB). Evaluation of preoperative ventricular function did not allow prediction of which patients would require VADs.

Steroid sensitivity of chronic uraemic and renal transplant patients measured by the antibody dependent cellular cytotoxicity reaction.

The steroid (methylprednisolone) sensitivity of chronic uraemic and renal transplant patients was examined on the basis of the extent of inhibition of the antibody-dependent cellular cytotoxicity (ADCC) reaction, and via the effect on the ADCC capacity test (ADCC-C). Individuals with an inhibition of 30% or more were classified as steroid-sensitive. Immunopharmacological tests and the clinical picture showed 67%, 12 of the 18 renal transplant patients to be steroid-sensitive.

Comparison of operative mortality and morbidity for initial and repeat coronary artery bypass grafting: The Coronary Artery Surgery Study (CASS) registry experience.

The National Heart, Lung, and Blood Institute's Coronary Artery Surgery Study (CASS) registry population was reviewed to allow comparison of operative mortality and morbidity rates for initial and repeat coronary artery bypass grafting (CABG) procedures. Standardized data collection was employed in CASS during patient entry (July 1, 1974, to May 31, 1979) and follow-up (ended November 30, 1982). Initial CABG was performed on 9,369 patients.

Detrimental effect of perioperative myocardial infarction on late survival after coronary artery bypass. Report from the Coronary Artery Surgery Study--CASS.

The influence of perioperative myocardial infarction on late survival after coronary artery bypass grafting was reviewed in 9,777 patients who underwent operation between 1974 and 1979. Definite or probable perioperative myocardial infarction was diagnosed in 561 patients (5.7%).

Sucrose transport into vacuoles isolated from barley mesophyll protoplasts.

Sucrose transport has been investigated in vacuoles isolated from barley mesophyll protoplasts. Rates of sucrose transfer across the tonoplast were even higher in vitro than in vivo indicating that the sucrose transport system had not suffered damage during isolation of the vacuoles. Sucrose transport is carrier-mediated as shown by substrate saturation of transport and sensitivity to a metabolic inhibitor and to competitive substrates.

[Fetal intracranial invasive cysts. Diagnosis, procedure and therapy using the example of a case report (arachnoid cyst)].

Changes of diagnosing foetal malformations via sonography are greatest with regard to the skull. Anencephalus or hydrocephalus are most frequent, whereas cysts are comparatively rare. In the case under report a large intracranial cyst was diagnosed during the 33rd week of pregnancy.

Potential for percutaneous transluminal coronary angioplasty before initial and repeat coronary artery bypass grafting in the Coronary Artery Surgery Study (CASS) Registry population.

Retrospective analysis of preoperative angiograms was conducted to determine potential candidacy for PTCA among the NHLBI Coronary Artery Surgery Study (CASS) Registry population undergoing initial and repeat CABG. Conservative criteria believed to be universally acceptable for PTCA were used. Patients were considered potential PTCA candidates if: (1) CABG had been performed to only 1 coronary artery system; (2) the critical disease was localized to the most proximal segment of that coronary artery system; (3) all distal segments of that coronary artery system were free of critical disease; and (4) the morphologic characteristics of the obstructing lesion were discrete and isolated.

Effect of neurointensive care upon outcome following severe head injuries in childhood--a preliminary report.

From March 1978 till August 1981 neurointensive care was applied to 24 children with severe head injuries (Glasgow Coma Scale less than or equal to 7, mean 5 +/- 1) corresponding to 7% of a population with head injuries observed during the same period. The neurointensive care included continuous intracranial and arterial pressure monitoring and normalization of intracranial and cerebral perfusion pressure with intubation, hyperventilation, control of body temperature, dexamethason, barbiturates and osmotic agents. The follow-up time is 1.

The clinical significance of bilateral synostosis of the lambdoid suture and the usefulness of its treatment.

Extended craniectomy has been employed in 148 +/- 4 month old infants with bilateral synostosis of lambdoid suture. Intraoperatively the ICP was less than 180 mm H2O in 6, 180-200 in 1, greater than 200 in 7. 18 +/- 10 months following surgery clinical signs as psychomotor retardation and so forth were present in 4 compared to 11 patients preoperatively.

Global left ventricular impairment and myocardial revascularization: determinants of survival.

Of 2,782 patients undergoing isolated coronary artery bypass grafting (CABG) from 1970 through 1979, 196 exhibited severe global impairment of left ventricular (LV) wall motion preoperatively (LV score, greater than or equal to 15; ejection fraction, less than 0.40 in all patients and less than 0.30 in 67%).

Typing of HLA antigens in a child population with nephrosis syndrome.

Using the microlymphocytotoxicity test of Terasaki, HLA--A, B, Cw antigen typing was done for 37 antigens in 28 children with steroid-sensitive nephrosis and five children with steroid-resistant nephrosis. Evaluation was made by the chi 2 test as corrected by the method of Yeates. In steroid-sensitive nephrosis the frequency of HLA--B 8 antigen was 33.

Monitoring of suppressor cell activity in nine renal transplant patients.

Function of Concanavalin A generated suppressor cells was serially tested on lymphocytes stimulated by mitogens, by a pool of test cells different in HLA-ABC and -DR, and by the kidney donor's cells preserved in liquid nitrogen. In six patients whose lymphocytes had strong suppressor cell activity, the kidney had a good function for 17-28 months (up to the time of the survey). In three patients who had practically no suppressor cell activity before and after transplantation, each kidney was rejected within 2-3 months.

CSF protein values in infants and children.

Total protein, albumin and gamma-globulin values were determined in CSF of 139 children. They had been referred to the emergency department of the Children's Hospital of the University of Berne during the last year because of suspected meningitis which, however, was not confirmed. In newborns and infants the normal range of protein values was wide, 0.

Results of coronary artery surgery in patients with poor left ventricular function (CASS).

We identified 420 medically treated and 231 surgically treated patients (coronary graft plus myocardial surgery in 30%) who had severe left ventricular dysfunction manifest by an ejection fraction below 0.36 and markedly abnormal wall motion. Compared with medically treated patients, those treated surgically had more severe angina (56.

Failure of Hancock xenograft valve: importance of valve position (4- to 9-year follow-up).

To evaluate long-term durability of Hancock valves, we reviewed our results in 107 hospital survivors (120 valves) who were operated on during 1974 through mid-1979. Mitral valve replacement was done in 63 patients, aortic valve replacement in 20, and mitral valve replacement combined with other procedures in 24. The 7-year survival was 84 +/- 4% (standard error of the mean) for 91 patients and 97 valves.