Publications by authors named "Kairui Xie"
Article Synopsis
- Diffuse Large B-cell lymphoma (DLBCL) is a prevalent form of non-Hodgkin lymphoma, prompting the investigation of susceptibility genes for personalized treatment solutions.
- The study utilized bioinformatics and in vitro techniques to identify candidate genes related to DLBCL, particularly focusing on ATOX1 and its role in impacting cell proliferation and MAPK pathway activation.
- ATOX1 was found to be significantly elevated in DLBCL cells, and its knockdown led to reduced cell growth and cell cycle changes, suggesting its potential as a therapeutic target in DLBCL treatment.
Hippocampal injury in the Alzheimer's disease (AD) pathological process is region-specific and magnetic resonance imaging (MRI)-based measures of localized hippocampus (HP) atrophy are known to detect region-specific changes associated with clinical AD, but it is unclear whether these measures provide information that is independent of that already provided by measures of total HP volume. Therefore, this study assessed the strength of association between localized HP atrophy measures and AD-related measures including cerebrospinal fluid (CSF) amyloid beta and tau concentrations, and cognitive performance, in statistical models that also included total HP volume as a covariate. A computational technique termed localized components analysis (LoCA) was used to identify 7 independent patterns of HP atrophy among 390 semiautomatically delineated HP from baseline magnetic resonance imaging of participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
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