New pentacyclic triterpenoids isolated from and their hepatoprotective activities on -butyl hydroperoxide-induced oxidative injury.

Eight unknown pentacyclic triterpenoids (1-4 and 8-11), along with eight known analogues (5-7 and 12-16) have been first isolated from the dried whole plant of . The structures of the new compounds were determined by comprehensive spectroscopic methods, including 1D and 2D NMR, as well as HRESIMS measurements. Meanwhile, the hepatoprotective activities of the isolated compounds were preliminarily evaluated, and the results indicated that compounds 2, 5 and 16 possess potent protective effects on -butyl hydroperoxide (-BHP)-induced oxidative injury , and further study revealed that 16 significantly alleviates -BHP-induced hepatotoxicity by effectively improving cell viability and decreasing reactive oxygen species (ROS) generation and the cell apoptosis rate in HepG2 cells.

Anti-inflammatory Cassane-Type Diterpenoids from the Seed Kernels of .

Eighteen cassane diterpenoids, including five new lactam-type (-), 12 new lactone-type (- and -), and one known compound (), were isolated from . To our knowledge, this is the first study on the seed kernels of , and cassane derivatives were discovered in this plant for the first time. Their structures including absolute configurations were established by extensive spectroscopic methods complemented with single-crystal X-ray diffraction analyses and ECD calculations.

New phenylpropanoid-conjugated pentacyclic triterpenoids from the whole plants of Leptopus lolonum with their antiproliferative activities on cancer cells.

Most of Euphorbiaceae plants are considered as folk medicinal plants because of their various pharmacological effects. However, there are eight Leptopus genus plants which belong to Euphorbiaceae have never be investigated. Thus, four Leptopus genus plants were collected to study their chemical constituents and pharmacological activities.

16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity and .

Barrigenol-like triterpenoids (BATs) showed promising anti-tumor, anti-inflammatory and anti-Alzheimer's activities, while, the inhibitory strength was usually affected by their states with aglycones or glycosides. In order to find more BATs as new anti-tumor agents with much more efficiency, the chemical and pharmaceutical studies were carried out on the acid hydrolysate product (AHP) of Semen Aesculi crude extract. Thirteen BATs, including three new aglycones (1-3), two new glycosides (4, 5) and eight known glycosides (6-13) were obtained.